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  1. Article

    Open Access

    Snail depletes the tumorigenic potential of glioblastoma

    Glioblastoma multiforme (GBM) is an aggressive brain malignancy characterized by high heterogeneity and invasiveness. It is increasingly accepted that the refractory feature of GBM to current therapies stems f...

    K Savary, D Caglayan, L Caja, K Tzavlaki, S Bin Nayeem, T Bergström, Y Jiang… in Oncogene (2013)

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    Article

    Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

    Gliomas are primary brain tumors mainly affecting adults. The cellular origin is unknown. The recent identification of tumor-initiating cells in glioma, which share many similarities with normal neural stem ce...

    N Lindberg, M Kastemar, T Olofsson, A Smits, L Uhrbom in Oncogene (2009)

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    Article

    Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

    SOX5 is a member of the high-mobility group superfamily of architectural non-histone proteins involved in gene regulation and maintenance of chromatin structure in a wide variety of developmental processes. So...

    E Tchougounova, Y Jiang, D Bråsäter, N Lindberg, M Kastemar, A Asplund… in Oncogene (2009)

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    Article

    Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

    In a subset of gliomas, the platelet-derived growth factor (PDGF) signaling pathway is perturbed. This is usually an early event occurring in low-grade tumors. In high-grade gliomas, the subsequent loss of the IN...

    E Tchougounova, M Kastemar, D Bråsäter, E C Holland, B Westermark, L Uhrbom in Oncogene (2007)