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Article
Open AccessEureka: objective assessment of the empty pelvis syndrome to measure volumetric changes in pelvic dead space following pelvic exenteration
Large tissue defects following pelvic exenteration (PE) fill with fluid and small bowel, leading to the empty pelvis syndrome (EPS). EPS causes a constellation of complications including pelvic sepsis and redu...
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Article
Open AccessPatients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC): quality of life and service use results
To describe trends and explore factors associated with quality of life (QoL) and psychological morbidity and assess breast cancer (BC) health service use over a 12-month period for patients joining the support...
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Article
The association of stressful life events on weight loss efforts among African American breast cancer survivors
This study examined whether stressful life events were associated with weight loss, central adiposity, and health behavior changes of African American breast cancer survivors (AABCS) participating in a weight ...
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Article
Open AccessDo drugs offering only PFS maintain quality of life sufficiently from a patient’s perspective? Results from AVALPROFS (Assessing the ‘VALue’ to patients of PROgression Free Survival) study
Trials of novel drugs used in advanced disease often show only progression-free survival or modest overall survival benefits. Hypothetical studies suggest that stabilisation of metastatic disease and/or sympto...
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Article
Therapeutic aims of drugs offering only progression-free survival are misunderstood by patients, and oncologists may be overly optimistic about likely benefits
The use of novel and often expensive drugs offering limited survival benefit in advanced disease is controversial. Treatment recommendations are influenced by patient characteristics and trial data showing ove...
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Article
Accurate prediction of BRCA1 and BRCA2 heterozygous genotypes using expression profiling of lymphocytes after irradiation-induced DNA damage
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Article
Low-coverage vaccination strategies for the conservation of endangered species
The Ethiopian wolf Canis simensis is a specialist carnivore found only in seven isolated mountain pockets in Ethiopia, where they prey on rodent communities. They live in family packs with an intricate social org...
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Article
Erratum: The DNA sequence and biological annotation of human chromosome 1
Nature 441, 315–321 (2006) We inadvertently omitted the names of the following authors: R. Banerjee, S. P. Bryant, D. C. Burford, W. D. H. Burrill, S. M. Clegg, P. Dhami, O. Dovey, L. M. Faulkner, S. M. Gribbl...
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Article
The DNA sequence and biological annotation of human chromosome 1
The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution. Here we report the finished sequence and biological annotation of human chrom...
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Article
Modelling the spread of scrapie in a sheep flock: evidence for increased transmission during lambing seasons
Presence of scrapie infectivity in the placenta suggests the possibility of increased transmission of scrapie during the lambing season. This hypothesis was explored here using a mathematical model of scrapie ...
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Article
DNA sequence and analysis of human chromosome 9
Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6–8% of humans, whereas pericentric inversions occur in more than 1% of th...
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Article
The DNA sequence and comparative analysis of human chromosome 10
The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentrom...
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Article
The DNA sequence and analysis of human chromosome 6
Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire ...
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Article
Femtosecond study of surface structure and composition and time-resolved spectroscopy in metals
Surface structuring and compositioning in aluminum alloy 2024-T3 were demonstrated using a femtosecond pulse laser. Surface nanostructuring was developed as a function of laser parameters and the surface micro...
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Article
Population dynamics of a scrapie outbreak
A detailed analysis of a scrapie outbreak in a flock of Cheviot sheep is described. A total of 33 cases of 1473 sheep born to the flock were reported between 1985 and 1994. The epidemiology of scrapie can onl...
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Article
The DNA sequence of human chromosome 22
Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, incl...
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Chapter and Conference Paper
A ROSAT EUV Survey of Coronal Activity in Nearby Stars and Cosmic Ray Injection into the Interstellar Medium
It has been argued by Shapiro (Proc 21st ICRC Moscow 2, 260, 1987 and references therein), that the dominant population of red dwarf stars provides the seed particles for a subsequent, interstellar medium base...
