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  1. No Access

    Article

    Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

    We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic cha...

    J Huan, N I Hornick, N A Goloviznina, A N Kamimae- Lanning, L L David… in Leukemia (2015)

  2. No Access

    Article

    Diagnostic and Therapeutic Potential of Tetanus Toxin-Derivatives in Neurological Diseases

    We assessed the ex vivo reactivity of peptidic constructs of Tet1 (analog of tetanus toxin non-virulent C fragment) with sequence homology to the cysteine-active site of thioredoxin (Tet1THO) or tetralysine (T...

    R. Kassa, V. Monterroso, L. L. David… in Journal of Molecular Neuroscience (2013)

  3. Article

    Open Access

    CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity

    Aminoglycoside-induced nephrotoxicity and ototoxicity is a major clinical problem. To understand how aminoglycosides, including gentamicin, induce cytotoxicity in the kidney proximal tubule and the inner ear, ...

    T Karasawa, Q Wang, L L David, P S Steyger in Cell Death & Disease (2010)

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  4. Article

    Lens cytoskeleton and transparency: A model

    The function of the cytoskeleton in lens was first considered when cytoplasmic microtubules were observed in elongating fibre cells of the chick lens nearly 40 years ago.1 Since that time, tubulin, actin, vimenti...

    J I Clark, J M Clark, L L David, H Matsushima in Eye (1999)

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