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Article
Open AccessWidespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonal...
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Article
Open AccessElevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study
Various lines of evidence suggest that brain bioenergetics and mitochondrial function may be altered in schizophrenia. On the basis of prior phosphorus-31 (31P)-magnetic resonance spectroscopy (MRS), post-mortem ...
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Article
Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study
Gamma-butyric acid (GABA) dysfunction has been implicated in the pathophysiology of schizophrenia and its cognitive deficits. Proton magnetic resonance spectroscopy (MRS) was used to test the hypothesis that o...
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Article
Open AccessAlterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation
We investigated in vivo neurochemical markers reflective of neuronal health and glial activation to determine if these could yield clues regarding the reduced fractional anisotropy (FA) of white matter and accele...