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Open AccessRegistration-free workflow for electromagnetic and optical navigation in orbital and craniofacial surgery
The accuracy of intra-operative navigation is largely dependent on the intra-operative registration procedure. Next to accuracy, important factors to consider for the registration procedure are invasiveness, t...
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Article
Open AccessVirtual splint registration for electromagnetic and optical navigation in orbital and craniofacial surgery
In intra-operative navigation, a registration procedure is performed to register the patient’s position to the pre-operative imaging data. The registration process is the main factor that determines accuracy o...
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Article
Open AccessMitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson’s disease
Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson’s disease (PD) and LRRK2 kinase inhibitors are currently being tested in early phase clinical trials. In or...
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Article
Open AccessCorrection to: Learning About Archaeology and Prehistoric Life
The original article unfortunately contains incorrect figures 6 to 13.
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Open AccessLearning About Archaeology and Prehistoric Life
This article is about an intervention introducing prehistoric life in primary education. Its objectives were to foster openness and interest for prehistory and archaeology, as well as content knowledge and con...
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Article
Factors associated with stereopsis and a good visual acuity outcome among children in the Infant Aphakia Treatment Study
To identify factors associated with stereopsis in children with good visual acuity after unilateral congenital cataract surgery in the Infant Aphakia Treatment Study.
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Open AccessIndependent and functional validation of a multi-tumour-type proliferation signature
Previously we demonstrated that an mRNA signature reflecting cellular proliferation had strong prognostic value. As clinical applicability of signatures can be controversial, we sought to improve our marker’s ...
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Open AccessEfficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The p...
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Open AccessRepeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo
The unique properties of the tumour microenvironment can be exploited by using recombinant anaerobic clostridial spores as highly selective gene delivery vectors. Although several recombinant Clostridium species ...
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Open AccessEvaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry
This study aimed to evaluate tumour hypoxia by comparing [18F]Fluoromisonidazole uptake measured using positron emission tomography ([18F]FMISO-PET) with immunohistochemical (IHC) staining techniques. Syngeneic r...
