4 Result(s)
within
L Dubois
English
Drug Resistance
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Article
Open AccessIndependent and functional validation of a multi-tumour-type proliferation signature
Previously we demonstrated that an mRNA signature reflecting cellular proliferation had strong prognostic value. As clinical applicability of signatures can be controversial, we sought to improve our marker’s ...
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Article
Open AccessEfficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The p...
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Article
Open AccessRepeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo
The unique properties of the tumour microenvironment can be exploited by using recombinant anaerobic clostridial spores as highly selective gene delivery vectors. Although several recombinant Clostridium species ...
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Article
Open AccessEvaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry
This study aimed to evaluate tumour hypoxia by comparing [18F]Fluoromisonidazole uptake measured using positron emission tomography ([18F]FMISO-PET) with immunohistochemical (IHC) staining techniques. Syngeneic r...
