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  1. Article

    Open Access

    Cdc2-like kinases: structure, biological function, and therapeutic targets for diseases

    The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12), catalyzing spliceosome...

    Mengqiu Song, Lu** Pang, Mengmeng Zhang… in Signal Transduction and Targeted Therapy (2023)

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  2. No Access

    Article

    A novel lncRNA MTAR1 promotes cancer development through IGF2BPs mediated post-transcriptional regulation of c-MYC

    Abnormal translation of the MYC proto-oncogene is a hallmark of the initiation and maintenance of tumorigenesis. However, the molecular mechanism underlying increased MYC protein levels in certain cancer types...

    Yunfeng Gao, Ming Jiang, Fangqin Guo, Xuejiao Liu, Qi Zhang, Sen Yang… in Oncogene (2022)

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    Article

    BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

    The low survival rate of esophageal squamous cell carcinoma patients is primarily attributed to technical limitations and a lack of insight regarding the molecular mechanisms contributing to its progression. A...

    Qiong Wu, Fangfang Liu, Mengmeng Ge, Kyle Vaughn Laster, Lixiao Wei, Ruijuan Du… in Oncogene (2022)

  4. No Access

    Article

    Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer

    Colon cancer is the most aggressive tumor in both men and women globally. As many the chemotherapeutic regimens have adverse side effects and contribute to the resistance and recurrence, therefore, finding nov...

    Guoguo **, Mingyang Yan, Kangdong Liu, Ke Yao, Hanyong Chen, Chengjuan Zhang… in Oncogene (2020)