51 Result(s)

Article

Mutations found in cancer patients compromise DNA binding of the winged helix protein STK19

Serine/threonine protein kinase 19 (STK19) has been reported to phosphorylate and activate oncogenic NRAS to promote melanomagenesis. However, concerns have been raised about whether STK19 is a kinase. STK19 h...

Jian Li, **nli Ma, **aoyu Wang, **aotong Hu, Shaobo Fang, Guoguo **… in Scientific Reports (2024)

Article

Domperidone inhibits cell proliferation via targeting MEK and CDK4 in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of digestive system tumor related death in the world. Unfortunately, effective chemopreventive agent is lack for patients with ESCC in cli...

Qiang Yuan, Yunshu Shi, Yuhan Zhang, Yaqian Shi… in Cancer Cell International (2024)

Article

Protein translation: biological processes and therapeutic strategies for human diseases

Protein translation is a tightly regulated cellular process that is essential for gene expression and protein synthesis. The deregulation of this process is increasingly recognized as a critical factor in the ...

Xuechao Jia, **nyu He, Chuntian Huang, Jian Li… in Signal Transduction and Targeted Therapy (2024)

Article

Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved in almost all cancer hallmark features including tumor proliferation, metastasis, angiogenesis, immunosuppression...

Yamei Hu, Zigang Dong, Kangdong Liu in Journal of Experimental & Clinical Cancer Research (2024)

Article

Targeting CRAF kinase in anti-cancer therapy: progress and opportunities

The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly dysregulated in human malignancies by processes driven by RAS or RAF oncogenes. Among the members of the RAF kinase family, CRAF plays...

Penglei Wang, Kyle Laster, Xuechao Jia, Zigang Dong, Kangdong Liu in Molecular Cancer (2023)

Article

Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer

Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal squamous cell carcinoma (ESCC) including low-grade and high-grade intraepithelial neoplasia. Due to the absence of molecular ind...

Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang… in Nature Communications (2023)

Article

TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway

T-LAK-originated protein kinase (TOPK), a dual specificity serine/threonine kinase, is up-regulated and related to poor prognosis in many types of cancers. Y-box binding protein 1 (YB1) is a DNA/RNA binding pr...

Wenjie Wu, Jialuo Xu, Dan Gao, Zhenliang **e, Wen**g Chen… in Cell Death & Disease (2023)

Article

CAFrgDB: a database for cancer-associated fibroblasts related genes and their functions in cancer

As one of the most essential components of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) interact extensively with cancer cells and other stromal cells to remodel TME and participate i...

Qiang Yuan, Yi Chu, **aoyu Li, Yunshu Shi, Yingying Chen, Jimin Zhao… in Cancer Gene Therapy (2023)

Article

Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC

Gastric cancer is the fourth leading cause of cancer deaths worldwide. Most patients are diagnosed in the advanced stage. Inadequate therapeutic strategies and the high recurrence rate lead to the poor 5-year ...

Mingzhu Li, Lina Duan, Wenjie Wu, Wen**g Li, Lili Zhao, Ang Li, Xuebo Lu… in Oncogenesis (2023)

Article

Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth

Although molecular targets such as HER2, TP53 and PIK3CA have been widely studied in esophageal cancer, few of them were successfully applied for clinical treatment. Therefore, it is urgent to discover novel a...

Xuechao Jia, Penglei Wang, Chuntian Huang… in Journal of Experimental & Clinical Cancer … (2023)

Article

Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2

Constitutive activation of RAS-RAF-MEK-ERK signaling pathway (MAPK pathway) frequently occurs in many cancers harboring RAS or RAF oncogenic mutations. Because of the paradoxical activation induced by a single...

Penglei Wang, Xuechao Jia, Bingbing Lu… in Signal Transduction and Targeted Therapy (2023)

Article

Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

Esophageal squamous cell carcinoma (ESCC) is an upper gastrointestinal cancer with high morbidity and mortality. New strategies are urgently needed to prolong patients’ survival. Through screening FDA-approved...

**nning Liu, Yanan Jiang, Hao Zhou, **aokun Zhao, Mingzhu Li… in Cell Death & Disease (2023)

Article

Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19

Ning Lu, Tingxuan Gu, Xueli Tian, Simin Zhao… in Signal Transduction and Targeted Therapy (2022)