Razoxane and Dexrazoxane - Two Multifunctional Agents
Experimental and Clinical Results
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Chapter
Summary and Outlook
Razoxane (Rz) and dexrazoxane (DXRz) have several interesting modes of action. They block the cell division at the level of G2/M in the cell cycle, they have shown antiinvasive activity in preclinical experiments...
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Chapter
Introduction
In chapter 1, the preface is followed by a short overview on the historical development of two bisdioxopiperazine derivatives razoxane (ICRF-159) and dexrazoxane (ICRF-187) which are the subject of this book. ...
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Chapter
Razoxane
In Chapter 2, preclinical and clinical data are given for razoxane, the older of the two drugs. The various modes of action of razoxane are briefly summarized, e.g. the block of the cell cycle in the G2/M phas...
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Chapter
Dexrazoxane
Dexrazoxane is highly effective in reducing anthracycline-induced cardiotoxicity and extravasation injury and is used clinically for these indications. Dexrazoxane has two potential pharmacological activities:...
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Article
Recognition of tumor blood vessel normalization as a new antiangiogenic concept
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Article
Commentary on zinc ligand-disrupted recombinant human Endostatin
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Article
Short communication: Metrazol enhances brain penetration and therapeutic efficacy of some anticancer agents: implications for brain metastases
The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic ...
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Article
Antitumour effect of RA 233 alone and combined with radiotherapy
The effect of RA233 alone or in combination with radiation was investigated in vivo on the 5180 sarcoma, the B16 melanoma and the Lewis lung carcinoma.
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Article
Effect of RA233 alone and combined with radiation on experimental tumour metastasis. Part 1
The effect of the platelet aggregation inhibitor RA233 alone or in combination with radiation was investigated on the spontaneously metastasizing B16 melanoma and on the Lewis lung carcinoma. The effect of thi...
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Article
Enhanced cerebrovascular permeability by Metrazol: significance for brain metastases
Metrazol enhanced the penetration of two proteins (125I human serum albumin and horseradish peroxidase), and the anticancer agent, razoxane, into the central nervous system of anaesthetized rats. Penetration was ...
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Article
Razoxane penetration into the cerebrospinal fluid of rats
Razoxane (100 mg/kg) was administered to rats as a single IP dose. Plasma and CSF samples were obtained at intervals varying from 15 min to 24 h after dosing, and the razoxane was assayed by a new and simple h...
