10 Result(s)
within
Kunxin **e
Life Sciences
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Article
TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation
The receptor-regulated Smad proteins are essential intracellular mediators of signal transduction by the transforming growth factor-β (TGF-β) superfamily of growth factors and are also important as regulators ...
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Article
Association of decreased expression of a Myb transcription factor with the TPD (tap** panel dryness) syndrome in Hevea brasiliensis
TPD (tap** panel dryness) is a complex physiological syndrome widely found in rubber tree (Hevea brasiliensis) plantations, which causes severe yield and crop losses in natural rubber-producing countries. The m...
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Article
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Transforming growth factor β (TGF-β) induces both apoptosis and cell-cycle arrest in some cell lines, but only growth arrest in others1. It is not clear how this differential response to TGF-β is specified. Smad ...
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Chapter
Smad Proteins in Apoptotic and Survival Signaling
Perhaps the most critical decision to be made during the life of a cell is whether to live or to die. Signaling events initiated by TGF-β superfamily cytokines play a critical role in specifying cell death and...
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Article
Ski and SnoN, potent negative regulators of TGF-β signaling
Ski and the closely related SnoN were discovered as oncogenes by their ability to transform chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and SnoN have also been reported in...
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Protocol
Three-dimensional Mammary Epithelial Cell Morphogenesis Model for Analysis of TGFß Signaling
Culturing mammary epithelial cells in laminin-rich extracellular matrices (three dimensional or 3D culture) offers significant advantages over that in the conventional two-dimensional (2D) tissue culture syste...
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Article
Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression
TAZ promotes growth, development and tumorigenesis by regulating the expression of target genes. However, the manner in which TAZ orchestrates the transcriptional responses is poorly defined. Here we demonstra...
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Article
Open AccessSimultaneous silencing of two different Arabidopsis genes with a novel virus-induced gene silencing vector
Virus-induced gene silencing (VIGS) is a useful tool for functional characterizations of plant genes. However, the penetrance of VIGS varies depending on the genes to be silenced, and has to be evaluated by ex...
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Article
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage
DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall elongating RNA polymerase II (Pol II) is not fully understoo...
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Article
Open AccessBlockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury
Mechanical spinal cord injury (SCI) is a deteriorative neurological disorder, causing secondary neuroinflammation and neuropathy. ADAM8 is thought to be an extracellular metalloproteinase, which regulates prot...
