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Article
Open AccessHER2-targeted therapies in cancer: a systematic review
Abnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2) are associated with the development of many tumors. It is currently a crucial treatment for multiple cancers. Advanced in...
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Article
Open AccessPyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) has been the most challenging subtype of BC, consisting of 20% of BC with an apparent correlation with poor prognosis. Despite that p...
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Article
Open AccessA method for multiple-sequence-alignment-free protein structure prediction using a protein language model
Protein structure prediction pipelines based on artificial intelligence, such as AlphaFold2, have achieved near-experimental accuracy. These advanced pipelines mainly rely on multiple sequence alignments (MSAs...