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  1. Article

    Open Access

    HER2-targeted therapies in cancer: a systematic review

    Abnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2) are associated with the development of many tumors. It is currently a crucial treatment for multiple cancers. Advanced in...

    Kunrui Zhu, **nyi Yang, Hebei Tai, **aorong Zhong, Ting Luo in Biomarker Research (2024)

  2. Article

    Open Access

    Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer

    Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) has been the most challenging subtype of BC, consisting of 20% of BC with an apparent correlation with poor prognosis. Despite that p...

    **aoxiao Liu, **ng Zhang, Zhiying Shao in Signal Transduction and Targeted Therapy (2023)

  3. Article

    Open Access

    A method for multiple-sequence-alignment-free protein structure prediction using a protein language model

    Protein structure prediction pipelines based on artificial intelligence, such as AlphaFold2, have achieved near-experimental accuracy. These advanced pipelines mainly rely on multiple sequence alignments (MSAs...

    **aomin Fang, Fan Wang, Lihang Liu, **gzhou He, Dayong Lin in Nature Machine Intelligence (2023)