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    Article

    Engineering of human brain organoids with a functional vascular-like system

    Human cortical organoids (hCOs), derived from human embryonic stem cells (hESCs), provide a platform to study human brain development and diseases in complex three-dimensional tissue. However, current hCOs lac...

    Bilal Cakir, Yangfei **ang, Yoshiaki Tanaka, Mehmet H. Kural in Nature Methods (2019)

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    Article

    Jetting Dispenser Height Effect on the Accuracy of Test Strip for Blood Glucose

    This study explores the application of Jetting Dispensers to dispense droplets of glucose oxidase enzyme solution onto blood test strips of immersion gold-plated printed circuit boards. Each droplet must conta...

    Kun-Yong Kim, Yi-Cheng Lee, Ho Chang in Journal of Medical and Biological Engineer… (2019)

  3. Article

    Open Access

    Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

    Embryonic stem cells (ESCs) maintain pluripotency through unique epigenetic states. When ESCs commit to a specific lineage, epigenetic changes in histones and DNA accompany the transition to specialized cell t...

    Kun-Yong Kim, Yoshiaki Tanaka, Juan Su, Bilal Cakir, Yangfei **ang in Nature Communications (2018)

  4. Article

    Open Access

    Dnmt1 regulates the myogenic lineage specification of muscle stem cells

    DNA methylation is an important epigenetic mark that regulates gene expression. Dnmt1 plays an important role in maintaining DNA methylation patterns on daughter DNA strands. Studies have shed light into the f...

    Ren**g Liu, Kun-Yong Kim, Yong-Wook Jung, In-Hyun Park in Scientific Reports (2016)