21 Result(s)
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Article
Open AccessHuman biodistribution and radiation dosimetry for the tau tracer [18F]Florzolotau in healthy subjects
Tau pathology plays a crucial role in neurodegeneration diseases including Alzheimer’s disease (AD) and non-AD diseases such as progressive supranuclear palsy. Tau positron emission tomography (PET) is an in-v...
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Detection of Alzheimer’s disease using ECD SPECT images by transfer learning from FDG PET
To develop a practical method to rapidly utilize a deep learning model to automatically extract image features based on a small number of SPECT brain perfusion images in general clinics to objectively evaluate...
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Article
Open AccessVisualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography
The 18F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, 18F-THK-5351 can also moni...
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[18F]FP-(+)-DTBZ PET study in a lactacystin-treated rat model of Parkinson disease
Lactacystin has been used to establish rodent models of Parkinson disease (PD), with cerebral α-synuclein inclusions. This study evaluated the uptake of [18F]9-fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-D...
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Open AccessBeta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study
Lack of treatment response in patients with late-life depression is common. The role of brain beta-amyloid (Aβ) deposition in treatment outcome in subjects with late-life depression remains unclear. The presen...
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Article
Imaging characteristic of dual-phase 18F-florbetapir (AV-45/Amyvid) PET for the concomitant detection of perfusion deficits and beta-amyloid deposition in Alzheimer’s disease and mild cognitive impairment
We investigated dual-phase 18F-florbetapir (AV-45/Amyvid) PET imaging for the concomitant detection of brain perfusion deficits and beta-amyloid deposition in patients with Alzheimer’s disease (AD) and amnestic m...
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Article
Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: 18F-florbetapir (AV-45/Amyvid) PET study
The objective of this study was to evaluate the amyloid burden, as assessed by 18F-florbetapir (AV-45/Amyvid) positron emission tomography PET, in patients with major depressive disorder (MDD) with different subt...
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Article
Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography
The literature suggests that a history of depression is associated with an increased risk of develo** Alzheimer’s disease (AD). The aim of this study was to examine brain amyloid accumulation in patients wit...
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Article
Perfusion-like template and standardized normalization-based brain image analysis using 18F-florbetapir (AV-45/Amyvid) PET
Amyloid positron emission tomography (PET) is an important noninvasive method for detecting amyloid burden in Alzheimer’s disease (AD) patients. As amyloid PET images have limited anatomical information, magne...
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Article
Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies: reply to Ballinger
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Article
Therapeutic outcome and prognosis in young patients with papillary and follicular thyroid cancer
Papillary and follicular thyroid cancer is a common malignancy in young patients, and the incidence of this cancer has been increasing. The aims of this study are to assess the clinical characteristics of papi...
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Article
In vivo imaging of radiation-induced tissue apoptosis by 99mTc(I)-his6-annexin A5
A recombinant annexin A5 with the N-terminal extension of six histidine residues was labeled with 99mTc(I)-tricarbonyl ion to produce the 99mTc-labeled annexin A5, referred to 99mTc(I)-his6-annexin A5. We have ex...
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Article
Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies
18F-Florbetapir (AV-45/Amyvid) is a novel positron emission tomography (PET) tracer for imaging plaque pathology in Alzheimer’s disease (AD), while PET images of fluorodeoxyglucose (FDG) for ce...
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Article
Fully Automatic Region of Interest Selection in Glomerular Filtration Rate Estimation from 99mTc-DTPA Renogram
Glomerular filtration rate (GFR) is a common accepted standard estimation of renal function. Gamma camera-based methods for estimating renal uptake of 99mTc-diethylenetriaminepentaacetic acid (DTPA) without blood...
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Article
Erratum to: Prevalence and significance of thyroid uptake detected by 18F-FDG PET
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Article
Prevalence and significance of thyroid uptake detected by 18F-FDG PET
In this retrospective study, we sought to investigate the prevalence and the clinical significance of thyroid uptake discovered by FDG PET/CT within the thyroid gland during imaging investigation of non-thyroi...
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Article
Well-Differentiated Thyroid Carcinoma with Concomitant Hashimoto’s Thyroiditis Present with Less Aggressive Clinical Stage and Low Recurrence
Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are the most common differentiated thyroid cancers. Previous studies report that Hashimoto’s thyroiditis (HT) concomitant with PTC is un...
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Noninvasive monitoring of tumor growth in a rat glioma model: comparison between neurological assessment and animal imaging
Malignant gliomas are the most common primary tumors that arise from glial cells and are characterized by extensive invasiveness and rapid progression. Limitation of the current therapeutic regimen for maligna...
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Article
Animal PET for Thioacetamide-Induced Rat Cholangiocarcinoma: A Novel and Reliable Platform
Cholangiocarcinoma (CCA) is a lethal disease afflicting many thousands of patients worldwide. We have previously developed an oral thioacetamide (TAA)-induced model of rat CCA that recapitulates the histologic...
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Improved accuracy of brain MRI/SPECT registration using a two-cluster SPECT normalization algorithm and a combinative similarity measure: application to the evaluation of Parkinson's disease
Single-photon emission computed tomography (SPECT) of dopamine transporters with technetium-99-labeled tropane derivative 99mTc-TRODAT-1 has recently been suggested to offer valuable information in assessing the ...
