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Article
Open AccessArtesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis
Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify safe and tolerable therapeut...
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Article
Open AccessThe temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells
Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin cap** protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains...
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Article
Open AccessAuthor Correction: ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression
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Article
Open AccessATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression
Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly understood how SCs enter cell c...
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Article
Open AccessControl of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (mem...
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Article
Open AccessTCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. By performing multiomic profiling, we recently uncovered super-enhancer heterogeneity between breast cancer s...
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Open AccessDefining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
Breast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet the functional role of cis-regulatory elements including super-enhancers in different breast cancer subtypes remains po...
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Article
Author Correction: CRISPR-assisted detection of RNA–protein interactions in living cells
A Correction to this paper has been published: https://doi.org/10.1038/s41592-021-01067-w
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CRISPR-assisted detection of RNA–protein interactions in living cells
We have developed CRISPR-assisted RNA–protein interaction detection method (CARPID), which leverages CRISPR–CasRx-based RNA targeting and proximity labeling to identify binding proteins of specific long non-co...
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Open AccessThe H2BG53D oncohistone directly upregulates ANXA3 transcription and enhances cell migration in pancreatic ductal adenocarcinoma
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Open AccessCancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes
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Open AccessTSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons
Testis-specific protein, Y-encoded-like 2 (TSPYL2) is an X-linked gene in the locus for several neurodevelopmental disorders. We have previously shown that Tspyl2 knockout mice had impaired learning and sensorimo...
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Article
Open AccessHistone H3 Mutations in Cancer
Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in...
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Article
Genomic instability in laminopathy-based premature aging
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenance of genomic integrity. Lamin A is a major component of the nuclear lamina and nuclear skeleton. Truncation i...
