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Article
Open AccessLearning pharmacometric covariate model structures with symbolic regression networks
Efficiently finding covariate model structures that minimize the need for random effects to describe pharmacological data is challenging. The standard approach focuses on identification of relevant covariates,...
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Protocol
Ex Vivo Working Porcine Heart Model
Ex vivo working porcine heart models allow for the study of a heart’s function and physiology outside the living organism. These models are particularly useful due to the anatomical and physiological similarit...
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Article
Open AccessEstimating the SARS-CoV-2 infected population fraction and the infection-to-fatality ratio: a data-driven case study based on Swedish time series data
We demonstrate that finite impulse response (FIR) models can be applied to analyze the time evolution of an epidemic with its impact on deaths and healthcare strain. Using time series data for COVID-19-related...
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Article
Open AccessPrevention of Ischemic Myocardial Contracture Through Hemodynamically Controlled DCD
Ischemic myocardial contracture (IMC) or “stone heart” is a condition with rapid onset following circulatory death. It inhibits transplantability of hearts donated upon circulatory death (DCD). We investigate ...
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Article
The effect of interventions on COVID-19
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Article
Open AccessClosed-loop regulation of arterial pressure after acute brain death
The purpose of this concept study was to investigate the possibility of automatic mean arterial pressure (MAP) regulation in a porcine heart-beating brain death (BD) model. Hemodynamic stability of BD donors i...
