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Article
Open AccessCombined adsorption and electrochemical oxidation of perfluorooctanoic acid (PFOA) using graphite intercalated compound
Perfluorooctanoic acid (PFOA) is a bioaccumulative synthetic chemical containing strong C–F bonds and is one of the most common per- and polyfluoroalkyl substances (PFAS) detected in the environment. Graphite ...
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Article
Open AccessKinetics of the ancestral carbon metabolism pathways in deep-branching bacteria and archaea
The origin of life is believed to be chemoautotrophic, deriving all biomass components from carbon dioxide, and all energy from inorganic redox couples in the environment. The reductive tricarboxylic acid cycl...
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Article
A mathematical study on the effects of a combination of an immune checkpoint inhibitor and a mutagen for anti-HIV-1 therapy
This study mathematically and computationally analyzes the effects of a combination of a chemical mutagen and an immune checkpoint inhibitor to develop an alternative anti-retroviral therapy. First, we address...
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Article
Open AccessMechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors
N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) and long-term depression (LTD) of signal transmission form neural circuits and thus are thought to underlie learning and memory. Thes...
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Article
A mathematical study for the development of anti-HIV-1 therapies based on the lethal mutagenesis method
This study tried to mathematically unveil the difficulties associated with an anti-HIV therapy based on the lethal mutagenesis method; two difficulties were identified. The first difficulty of this method was ...
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Chapter
A Theoretical Basis for an Acquired Immunodeficiency Syndrome Treatment by a Mutagenesis Approach
The multidrug therapy for Acquired ImmunoDeficiency Syndrome (AIDS) is efficacious in suppressing viral load but it is an inappropriate treatment for AIDS patients suffering from side effects of anti-Human Imm...
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Article
Emergence of observable rules in a spatial game system
This study focuses on player’s strategies observed from outside our original spatial game iterated by players, each of which is placed in a lattice site on a two-dimensional square lattice. A particularity of ...
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Article
Chronic kidney diseases of uncertain etiology (CKDue) in Sri Lanka: geographic distribution and environmental implications
The increase in the number of chronic kidney disease (CKD) patients from the north central region of Sri Lanka has become a environmental health issue of national concern. Unlike in other countries where long-...
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Chapter and Conference Paper
Toward Elucidation of Longevity of Immunological Memory
An interesting and substantial feature of the immune memory is its eventual loss, namely “longevity”. An extension of longevity is a significant issue for efficacy of vaccines. We have discussed possible mecha...
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Chapter and Conference Paper
A Note on Dynamical Behaviors of a Spatial Game Operated on Intercrossed Rules
The present study discusses a twist in hierarchical rules embedded in a spatial game system. In the typical spatial games, each player has its own strategy, and determines its action on the strategy; its actio...
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Article
A time-dependent threshold condition to determine the onset of AIDS
This study first considers the effects of “uninfectious” HIV-1 due to fatal mutations, and then analysis reveals that AIDS develops when the number of HIV-1 strains, i.e., antigenic diversity, is above a “time...
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Article
A hub gene in an HIV-1 gene regulatory network is a promising target for anti-HIV-1 drugs
The existing anti-HIV-1 drugs have troublesome problems with side-effects and the development of drug resistance, etc. To avoid these problems by using our knowledge of complex network analyses, this study exa...
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Chapter and Conference Paper
A Network Approach for HIV-1 Drug Resistance Prevention
In AIDS treatments, it is an imperative problem to reduce the risk of the drug resistance. The previous study discussed which HIV-1 gene products are an ideal drug target not to develop drug resistance by appl...
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Article
Antibody-based computing
An application of the antibody’s flexible recognition (i.e. multi-reactivity) to antigenic epitopes to a combinatorial computing is just getting started. The present study discusses an antibody-based computati...
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Chapter and Conference Paper
Fatal Mutations in HIV Population as an Influential Factor for an Onset of AIDS
It is well known that mutations occur at high rate at the replication of HIV genome. Mutations on the gene encoding requisite proteins for infection to host cells deprive ability to infect to them, thus such m...
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Chapter and Conference Paper
Mutation Probability Threshold of HIV for AIDS
As a theory on a deciding factor leading to AIDS, ”antigenic diversity threshold theory” has been offered by Nowak et al. This theory mentions AIDS develops when a number of mutant strains from a single HIV sw...
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Chapter and Conference Paper
Tolerance Dependent on Timing/Amount of Antigen-Dose in an Asymmetric Idiotypic Network
Physiological experiments demonstrate establishment of immunological tolerance is controlled by dose-timing and dose-amount of an antigen. My previous study reproduced the tolerance dependent on dose-timing of...
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Chapter and Conference Paper
Emergence of Immune Memory and Tolerance in an Asymmetric Idiotype Network
This study proposes an idiotype network model system adopted an “asymmetric” idiotype – anti-idiotypic interaction, and shows realizing immune tolerance as well as immune memory on a transient dynamics. To dat...
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Chapter and Conference Paper
A Switching Memory Strategy in an Immune Network Model
As an empirical knowledge on vaccination, it is known that immune memories against viral antigens (i.e., self-reproductive antigens) are sustained for a very long period more than 10 years, whereas against non...
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Chapter and Conference Paper
Mechanism of a Transient but Long-Lasting Immune Memory Function on a Self/Non-Self Boundary
Our previous study proposed an immune network model with evolving dynamics for antigen-specificity of a lymphocyte receptor, and obtained the following results: 1) the model revealed threshold dynamics to dete...
