-
Article
Open AccessThrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating regeneration of the bone marrow (BM), namely the hematopoi...
-
Article
Open AccessInvolution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway
Aging, chronic high-fat diet feeding, or housing at thermoneutrality induces brown adipose tissue (BAT) involution, a process characterized by reduction of BAT mass and function with increased lipid droplet si...
-
Article
The genesis of brown fat—a smooth muscle origin story revisited
Brown adipose tissue acquires increased thermogenic capacity with prolonged cold exposure through de novo recruitment of brown adipocytes. Studies by Shamsi et al. and Angueira et al. identify novel cellular o...
-
Article
Thermal stress induces glycolytic beige fat formation via a myogenic state
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces...
-
Article
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
Calcium cycling induced by the SERCA2b–RyR2 pathway in beige fat cells allows for thermogenic activity independent of UCP1.
-
Article
Genetic and functional characterization of clonally derived adult human brown adipocytes
Clonally-derived cell lines of human preadipocytes from BAT biopsies allows for the genetic and functional characterization of adipocytes from this tissue
-
Article
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Brown adipose tissue-enriched lysine methyltransferase EHMT1 is an essential enzyme in the PRDM16–C/EBP-β transcriptional complex that controls brown adipose cell fate and energy metabolism.
-
Article
Open AccessA medium-chain fatty acid as an alternative energy source in mouse preimplantation development
To further optimize the culturing of preimplantation embryos, we undertook metabolomic analysis of relevant culture media using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). We detecte...
-
Article
Open AccessHybGFS: a hybrid method for genome-fingerprint scanning
Protein identification based on mass spectrometry (MS) has previously been performed using peptide mass fingerprinting (PMF) or tandem MS (MS/MS) database searching. However, these methods cannot identify prot...
-
Article
Open AccessGEM System: automatic prototy** of cell-wide metabolic pathway models from genomes
Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling approaches to cell simulation are labor-intensive, manual...
-
Chapter
The Genome-Based E-CELL Modeling (GEM) System
