5 Result(s)
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Article
Develo** TRAIL/TRAIL death receptor-based cancer therapies
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The ac...
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Open AccessEpidemiological trends of women’s cancers from 1990 to 2019 at the global, regional, and national levels: a population-based study
Every year around the world, more than 2 million women are diagnosed with breast cancer and genital tract cancers. However, there are rare studies comprehensively describing the global and regional trends of i...
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Article
Open AccessRetinal determination gene networks: from biological functions to therapeutic strategies
The retinal determinant gene network (RDGN), originally discovered as a critical determinator in Drosophila eye specification, has become an important regulatory network in tumorigenesis and progression, as well ...
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Article
Open AccessS100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1
S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting ...
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Open AccessSimultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with...
