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  1. Article

    Open Access

    Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling

    Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with...

    **min Tan, Deguang Kong, Zhuoli Tao, Fangling Cheng, Baoyuan Zhang… in Biomarker Research (2024)

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  2. No Access

    Article

    Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling

    Epidermal growth factor receptor (EGFR) gene amplification and mutation occurs most frequently in glioblastoma (GBM). However, EGFR-tyrosine kinase inhibitors (TKIs), including gef...

    Minhai Dong, Qungen **ao, **yang Hu, Fangling Cheng, Po Zhang… in Cancer Gene Therapy (2020)

  3. Article

    Open Access

    MET in glioma: signaling pathways and targeted therapies

    Gliomas represent the most common type of malignant brain tumor, among which, glioblastoma remains a clinical challenge with limited treatment options and dismal prognosis. It has been shown that the dysregula...

    Fangling Cheng, Dongsheng Guo in Journal of Experimental & Clinical Cancer Research (2019)

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  4. No Access

    Article

    Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells

    Glioblastoma (GBM) is the most aggressive brain tumor and resistant to current available therapeutics, such as radiation. To improve the clinical efficacy, it is important to understand the cellular mechanisms...

    Lei Zhang, Fangling Cheng, Yiju Wei, Lijun Zhang, Dongsheng Guo, Baofeng Wang… in Oncogene (2019)