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Article
An ultra-sensitive biosensor for circulating microRNA detection with Fe single-atom enhanced cathodic luminol-O2 electrochemiluminescence
Circulating microRNAs (miRNAs) play a pivotal role in the occurrence and development of acute myocardial infarction (AMI), and precise detection of them holds significant clinical implications. The development...
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Article
A IISNPs panel for the giant panda (Ailuropoda melanoleuca)
The giant panda (Ailuropoda melanoleuca), as an endemic species of China, is also a flagship species of wildlife Conservation. However, the accuracy of individual identification of giant pandas is typically probl...
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Article
Stratigraphic classification of the Quaternary North Hebei Plain using geophysical methods
The North Hebei Plain is a typical example of a deep-covered area, with a thickness of more than 200 m Quaternary loose sediments. Previous studies have tried various stratigraphic classification methods but l...
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Article
Recent advances and applications of single atom catalysts based electrochemical sensors
Single atom catalysts (SACs) have attracted considerable attention due to their unique structures and excellent catalytic performance, especially in the area of catalysis science and energy conversion and stor...
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Article
Open AccessThe enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling
The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint regulation, has become a focal point in cancer immunotherapy. In the context of cancer, upregulated PD-L1 on tumor cells ...
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Article
Development of SNP markers to identify the sex of the giant panda from naturally degraded fecal samples
A non-invasive, fast, and reliable method for sex identification of the giant panda (Ailuropoda melanoleuca) was developed by genoty** five SNPs located at the sex chromosome amelogenin (AMEL) paralogs. The gia...
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Article
Open AccessSimultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with...
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Article
Achieving physical blocking and chemical electrocatalysis of polysulfides by using a separator coating layer in lithium–sulfur batteries
The persistent challenges in slow redox reaction kinetics and the consequential issue of polysulfide shuttling still restrict the practical utilization of lithium-sulfur (Li–S) batteries. To address these prob...
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Article
Elucidating and manipulating pressure-induced water intrusion–extrusion in tunable hydrophobic Co/Zn bimetallic ZIFs: Roles of pore size and hydrogen bond
Porous heterogeneous lyophobic systems (HLSs) find potential applications in energy restoring, dissipating, and absorbing. However, the development of controllable HLSs still lacks rational structure design of...
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Article
Open AccessS100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1
S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting ...
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Article
Open AccessNew insights into the stemness of adoptively transferred T cells by γc family cytokines
T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthrough of chimeric antigen receptor therapy (CAR-T) in hematologic malignancies. It relie...
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Article
Open AccessExploiting innate immunity for cancer immunotherapy
Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosup...
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Article
Genetic parameter estimates for estrus duration and urinary hormone levels in captive female giant pandas
In captive giant pandas (Ailuropoda melanoleuca), both urinary estrogen and progesterone levels have been dynamically measured and routinely involved in the assisted reproduction. Yet the genetic contribution to ...
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Article
Open AccessFocal adhesion kinase: from biological functions to therapeutic strategies
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functions, such as proliferation, survival, migration, and invasion. In addition, FAK regulate...
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Article
Use of food attractants to monitor and forecast Spodoptera frugiperda (J. E. Smith) seasonal abundance in southern China
The fall armyworm [FAW, Spodoptera frugiperda (J. E. Smith)] is an important invasive pest of maize crops in Africa, Asia and the Middle East. To enable timely and effective pest management, accurate monitoring a...
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Article
Open AccessRecent advances in targeted strategies for triple-negative breast cancer
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer, negatively expresses estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2 (HER2). Altho...
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Article
Open AccessSynergistic efficacy of simultaneous anti-TGF-β/VEGF bispecific antibody and PD-1 blockade in cancer therapy
Recently, therapeutic antibodies against programmed cell death 1 (PD-1) and its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However, blocking the PD-1/PD-L1 axis alone is not s...
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Article
Multiaxial notch fatigue probability modeling based on three-parameter Weibull distribution and effective strain energy density
Multiaxial fatigue life analysis of notched specimens is a critical issue for structural integrity design. However, there is still a lack of multiaxial fatigue life prediction models with coupled notch effect ...
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Article
Cu1-B dual-active sites catalysts for the efficient dehydrogenative coupling and CO2 electroreduction
Dual-active sites (DASs) catalysts have positive potential applications in broad fields because of their specific active sites and synergistic catalytic effects. Therefore, the controllable synthesis and finel...
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Article
ZIF-8@ZIF-67 Derived Co/NPHC Catalysts for Efficient and Selective Hydrogenation of Nitroarenes
Constructing nitrogen-doped porous hollow carbon with loading of non-precious metal for highly efficient hydrogenation of nitroarenes is desirable but challenging. Herein we report a facile self-sacrificing te...
