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  1. Article

    Open Access

    Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

    The purpose of this study was to investigate the profile of histone deacetylase (HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of normal control and osteoarthritis (OA...

    Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi… in Arthritis Research & Therapy (2010)

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  2. No Access

    Article

    Efficacy and safety of tacrolimus treatment for rheumatoid arthritis patients undergoing hemodialysis

    Rheumatoid arthritis (RA) is an autoimmune disorder characterized by progressive joint destruction that requires aggressive treatment using appropriate disease-modifying antirheumatic drugs (DMARDs). RA patien...

    Misuzu Yamashita, Masamitsu Natsumeda, Koji Takasugi, Akiko Ueno… in Modern Rheumatology (2008)

  3. Article

    Open Access

    Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis

    Despite its potent ability to inhibit proinflammatory cytokine synthesis, interleukin (IL)-10 has a marginal clinical effect in rheumatoid arthritis (RA) patients. Recent evidence suggests that IL-10 induces m...

    Koji Takasugi, Masahiro Yamamura, Mitsuhiro Iwahashi… in Arthritis Research & Therapy (2006)

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