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  1. Article

    Open Access

    Anxiolytic effects of Enterococcus faecalis 2001 on a mouse model of colitis

    Ulcerative colitis (UC) is a refractory inflammatory bowel disease, which is known to cause psychiatric disorders such as anxiety and depression at a high rate in addition to peripheral inflammatory symptoms. ...

    Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Kazuya Miyagawa in Scientific Reports (2024)

  2. Article

    Open Access

    Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice

    Angiotensin (Ang)-converting-enzyme (ACE) 2 converts Ang II into Ang (1–7), which in turn acts on MAS receptors (ACE2/Ang (1–7)/MAS receptors pathway). This pathway has neuroprotective properties, making it a ...

    Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata in Molecular Brain (2023)

  3. Article

    Open Access

    Reorganization of the ancestral sex-determining regions during the evolution of trioecy in Pleodorina starrii

    The coexistence of three sexual phenotypes (male, female and bisexual) in a single species, ‘trioecy’, is rarely found in diploid organisms such as flowering plants and invertebrates. However, trioecy in haplo...

    Kohei Takahashi, Shigekatsu Suzuki, Hiroko Kawai-Toyooka in Communications Biology (2023)

  4. Article

    Open Access

    Small grant subsidy application effects on productivity improvement: evidence from Japanese SMEs

    This study examines the effects of a small grants subsidy on small- and medium-sized enterprises’ (SMEs) productivity. Using rich Japanese firm-level data, we analyze the effects of both applying for and recei...

    Kohei Takahashi, Yuki Hashimoto in Small Business Economics (2023)

  5. Article

    Open Access

    Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19

    Coronavirus disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure is associated with high mortality. The pathogenesis of COVID-19 is associated with microembolism or microvascular endo...

    Fumihiro Ogawa, Yasufumi Oi, Kento Nakajima, Reo Matsumura in Thrombosis Journal (2021)

  6. No Access

    Article

    Establishment of human airway epithelial cells with doxycycline-inducible cell growth and fluorescence reporters

    We previously reported the successful establishment of multiple immortalized cell lines that preserved the original nature of the primary cells via co-expression of R24C mutant cyclin-dependent kinase 4 (CDK4R24C

    Ai Orimoto, Kohei Takahashi, Masaki Imai, Tohru Kiyono, Yoshihiro Kawaoka in Cytotechnology (2021)

  7. No Access

    Chapter and Conference Paper

    A Web-Based Attendance Management System with NFC Seat Identifiers

    We present a web-based system for managing student attendance by exploiting the capability of NFC tag to invoke the web browser to access the URL written in the tag. Suppose an NFC tag sticker is pasted at eac...

    Kohei Takahashi, Michitoshi Niibori in Advances in Networked-Based Information Sy… (2021)

  8. No Access

    Article

    Evaluation of primer pairs for studying arbuscular mycorrhizal fungal community compositions using a MiSeq platform

    Although many primers have been proposed for arbuscular mycorrhizal fungi (AMF)–specific sequencing, only a few studies have evaluated suitable primer pairs for MiSeq analysis. Here, we analyzed AMF community ...

    Kazuki Suzuki, Kohei Takahashi, Naoki Harada in Biology and Fertility of Soils (2020)

  9. Article

    Peculiarities of biofilm formation by Paracoccus denitrificans

    Most bacteria form biofilms, which are thick multicellular communities covered in extracellular matrix. Biofilms can become thick enough to be even observed by the naked eye, and biofilm formation is a tightly...

    Kana Morinaga, Keitaro Yoshida, Kohei Takahashi in Applied Microbiology and Biotechnology (2020)

  10. Article

    Open Access

    Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain–gut axis

    Patients with inflammatory bowel disease (IBD), including those with ulcerative colitis and Crohn’s disease, have higher rates of psychiatric disorders, such as depression and anxiety; however, the mechanism o...

    Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto in Journal of Neuroinflammation (2019)

  11. No Access

    Article

    Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system

    Olfactory bulbectomy (OBX) in rodents is considered a putative animal model of depression. It has been reported that some abnormal behaviors observed in this animal model of depression involve dopaminergic neu...

    Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takeharu Nakajima in Psychopharmacology (2016)

  12. No Access

    Chapter and Conference Paper

    Exploiting No-SQL DB for Implementing Lifelog Mashup Platform

    To support efficient integration of heterogeneous lifelog service, we have previously proposed and implemented a lifelog mashup platform consisting of the lifelog common data model (LLCDM) and the lifelog mashup ...

    Kohei Takahashi, Shinsuke Matsumoto, Sachio Saiki in Soft Computing in Big Data Processing (2014)

  13. No Access

    Chapter

    Stress Distribution of the Spinal Cord and Clinical Relevance in Cervical Spondylotic Myelopathy

    Intramedullary stress was analyzed in patients with cervical spondylotic myelopathy (CSM) using a finite element method (FEM). A total of 99 disc levels of 30 patients with CSM were analyzed and divided into...

    Kohei Takahashi, Hiroshi Ozawa in Neuroprotection and Regeneration of the Sp… (2014)

  14. Article

    Effects of low and high levels of moderate hypoxia on anaerobic energy release during supramaximal cycle exercise

    Yuji Ogura, Shizuo Katamoto, ** Uchimaru in European Journal of Applied Physiology (2006)

  15. No Access

    Article

    Effects of low and high levels of moderate hypoxia on anaerobic energy release during supramaximal cycle exercise

    The purpose of this study was to investigate whether hypoxia can alter anaerobic energy release during supramaximal exercise. Seven male subjects performed 12 submaximal cycling tests to establish the relation...

    Yuji Ogura, Shizuo Katamoto, ** Uchimaru in European Journal of Applied Physiology (2006)