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Article
Open AccessBasophil activation in insect venom allergy: comparison of an established test using liquid reagents with a test using 5-color tubes with dried antibody reagents
Flow cytometry-based basophil activation tests (BAT) have been performed with various modifications, differing in the use of distinct identification and activation markers. Established tests use liquid reagent...
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Article
Open AccessA new way forward? Examining the potential of quantitative analysis of IgE datasets
Allergies constitute an important public health problem, and epidemiological data is crucial to develo** strategies for its prevention and therapy. Few population-based studies are available for data on alle...
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Article
Open AccessComprehensive characterization of central BCL-2 family members in aberrant eosinophils and their impact on therapeutic strategies
Hypereosinophilia represents a heterogenous group of severe medical conditions characterized by elevated numbers of eosinophil granulocytes in peripheral blood, bone marrow or tissue. Treatment options for hyp...
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Article
Open AccessAnaphylaxis: subjective symptom reports of patients with a special focus on “near-death” experiences
Almost all anaphylactic reactions are associated with subjective symptoms, which are also referred to “prodromi”, and are often not taken seriously. In 100 patients categorized with different severity grades, ...
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Article
Open AccessMessages for patients and relatives from the 2021 update of the guideline on acute therapy and management of anaphylaxis
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Article
Open AccessPractical handling of allergic reactions to COVID-19 vaccines
For the preventive treatment of the 2019 coronavirus disease (COVID-19) an unprecedented global research effort studied the safety and efficacy of new vaccine platforms that have not been previously used in hu...
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Article
Open AccessGuideline (S2k) on acute therapy and management of anaphylaxis: 2021 update
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Article
Open AccessPredominant patterns of β-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins
Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsi...
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Article
Open AccessGuideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Societ...
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Article
Open AccessClinical and serological follow-up of patients with WDEIA
The clinical threshold in wheat-dependent, exercise-induced anaphylaxis seems to be lowered in patients on wheat free diet, whereas the opposite is seen in patients on regular wheat intake. Therefore, a recomm...
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Article
Open AccessCofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers
In wheat-dependent exercise-induced anaphylaxis (WDEIA), cofactors such as exercise, acetylsalicylic acid (ASA), alcohol or unfavorable climatic conditions are required to elicit a reaction to wheat products. ...
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Article
Open AccessPerioperative drug reactions – practical recommendations for allergy testing and patient management
Allergy testing for perioperative drug reactions poses a particular diagnostic challenge. Neuromuscular blocking agents (NMBA) and antibiotics are among the most common triggers. In principle, however, any dru...
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Article
Open AccessCytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop
The mechanisms how environmental compounds influence the human immune system are unknown. The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immune-modulating functions and ...
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Article
Open AccessNon-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?
It is hypothesized that because of higher mast cell numbers and mediator release, mastocytosis predisposes patients for systemic immediate-type hypersensitivity reactions to certain drugs including non-steroid...
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Article
Open AccessResearch needs in allergy: an EAACI position paper, in collaboration with EFA
In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to ...
