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Article
Open AccessBasophil activation in insect venom allergy: comparison of an established test using liquid reagents with a test using 5-color tubes with dried antibody reagents
Flow cytometry-based basophil activation tests (BAT) have been performed with various modifications, differing in the use of distinct identification and activation markers. Established tests use liquid reagent...
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Article
Open AccessA new way forward? Examining the potential of quantitative analysis of IgE datasets
Allergies constitute an important public health problem, and epidemiological data is crucial to develo** strategies for its prevention and therapy. Few population-based studies are available for data on alle...
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Article
Refined diagnostic criteria for bone marrow mastocytosis: a proposal of the European competence network on mastocytosis
In the current classification of the World Health Organization (WHO), bone marrow mastocytosis (BMM) is a provisional variant of indolent systemic mastocytosis (ISM) defined by bone marrow involvement and abse...
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Article
Open AccessComprehensive characterization of central BCL-2 family members in aberrant eosinophils and their impact on therapeutic strategies
Hypereosinophilia represents a heterogenous group of severe medical conditions characterized by elevated numbers of eosinophil granulocytes in peripheral blood, bone marrow or tissue. Treatment options for hyp...
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Chapter
Hypersensitivity Reactions to Iodinated Radiocontrast Media
Radio contrast media (RCM) are among the most common elicitors of drug hypersensitivity reactions due to their increasing use in iodinated X-ray images and computed tomography. Immediate hypersensitivity react...
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Chapter
Documentation for Patients with Drug Hypersensitivity: Allergy Pass and Allergy Card
Drug hypersensitivity reactions (DHR) may be severe, life-threatening, and even fatal [1]. Readministration of a culprit drug for DHR is the most important risk factor for recurrence, and may cause more severe...
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Chapter
Drug Hypersensitivity and Clonal Mast Cell Disorders
Anaphylaxis is common in adult patients with mastocytosis. Triggers of anaphylaxis in patients with mastocytosis are predominantly hymenoptera venoms and idiopathic. There is the concern that drug anaphylaxis ...
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Chapter
Peri-Interventional Hypersensitivity: Anesthetic Drugs and Materials
Hypersensitivity reactions in the perioperative period are challenging. Surgical routine or emergency procedures include a variety of problems, including administration of often several pre-, intra-, and posto...
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Chapter
Cutaneous Signs and Syndromes of Drug Hypersensitivity
The skin is the organ which is most frequently involved in drug hypersensitivity (DH) [1]. Multiple cutaneous reaction types have been attributed to DH. However, in patients with confirmed cutaneous drug hyper...
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Chapter
Diagnostic Agents
Hypersensitivity to diagnostic agents may be caused by allergic and nonallergic mechanisms. Immediate hypersensitivity reactions (IHRs) with anaphylaxis are common to iodinated radiocontrast media (RCM), gadol...
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Chapter
Antiepileptic and Psychotropic Drugs
According to the WHO [1], approximately 50 million adults and approximately ten million children [2] suffer from epilepsy worldwide; in the USA approximately three million adults and 0.5 million children are a...
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Reference Work Entry In depth
Immediate-Type Allergy: Rhinoconjunctivitis, Asthma, Anaphylaxis
Immediate-type allergies have increased significantly in frequency in the last decades of the twentieth century, but the causes of this have ultimately not been clarified. The following prevalence, moderately ...
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Reference Work Entry In depth
Basic Principles in Allergology and Hypersensitivity Reactions
Many clinical presentations in dermatology are based on hypersensitivity reactions, which may be caused by toxic effects, intolerance reactions or immune adverse events. For a better understanding, the classif...
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Article
Open AccessAnaphylaxis: subjective symptom reports of patients with a special focus on “near-death” experiences
Almost all anaphylactic reactions are associated with subjective symptoms, which are also referred to “prodromi”, and are often not taken seriously. In 100 patients categorized with different severity grades, ...
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Article
Open AccessMessages for patients and relatives from the 2021 update of the guideline on acute therapy and management of anaphylaxis
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Article
Open AccessPractical handling of allergic reactions to COVID-19 vaccines
For the preventive treatment of the 2019 coronavirus disease (COVID-19) an unprecedented global research effort studied the safety and efficacy of new vaccine platforms that have not been previously used in hu...
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Article
Penicillin-Toleranzinduktion in der Schwangerschaft
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Article
Open AccessGuideline (S2k) on acute therapy and management of anaphylaxis: 2021 update
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Article
Open AccessPredominant patterns of β-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins
Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsi...
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Article
Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry
Systemic mastocytosis (SM) is frequently associated with eosinophilia. To examine its prevalence and clinical impact in all WHO classification-based subcategories, we analyzed eosinophil counts in 2350 mastocy...
