5 Result(s)
within
Kirsten D. Mertz
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessTwo distinct immunopathological profiles in autopsy lungs of COVID-19
Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune med...
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Article
Open AccessB cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor as...
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Article
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα
Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby changing human breast cell fate.
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Article
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
In mouse models of breast cancer, anti-CCL2 therapy—thought to be potentially useful in treating cancer—is shown to accelerate the growth of lung metastases on discontinuation due to a surge of recruitment of ...
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Article
MTSS1 is a metastasis driver in a subset of human melanomas
In cancers with a highly altered genome, distinct genetic alterations drive subsets rather than the majority of individual tumours. Here we use a sequential search across human tumour samples for transcript ou...
