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Article
Open AccessSwiss digital pathology recommendations: results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology
Integration of digital pathology (DP) into clinical diagnostic workflows is increasingly receiving attention as new hardware and software become available. To facilitate the adoption of DP, the Swiss Digital P...
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Article
Open AccessDigital image analysis and artificial intelligence in pathology diagnostics—the Swiss view
Digital pathology (DP) is increasingly entering routine clinical pathology diagnostics. As digitization of the routine caseload advances, implementation of digital image analysis algorithms and artificial inte...
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Article
Using autopsies to dissect COVID-19 pathogenesis
The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19. Suitable models were missing at the beginning of the pandemic, and studies investigating disease pathogenesis relied on p...
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Article
Open AccessCorrelation between structural heart disease and cardiac SARS-CoV-2 manifestations
The prognosis of COVID-19 patients with cardiac involvement is unfavorable and it remains unknown which patients are at risk. The virus enters cells via its receptor angiotensin-converting enzyme 2 (ACE2). Myo...
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Article
Open AccessTwo distinct immunopathological profiles in autopsy lungs of COVID-19
Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune med...
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Article
Open AccessCorrelates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology
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Article
Open AccessB cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor as...
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Article
Open AccessPrecision immunoprofiling by image analysis and artificial intelligence
Clinical success of immunotherapy is driving the need for new prognostic and predictive assays to inform patient selection and stratification. This requirement can be met by a combination of computational path...
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Article
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvig...
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Article
Tumor infiltrating lymphocytes in lymph node metastases of stage III melanoma correspond to response and survival in nine patients treated with ipilimumab at the time of stage IV disease
Prognosis of metastatic melanoma improved with the development of checkpoint inhibitors. The role of tumor infiltrating lymphocytes (TILs) in lymph node metastases of stage III melanoma remains unclear. We ret...
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Article
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα
Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby changing human breast cell fate.
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Article
Open AccessGrover’s-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy
Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand 1 (P...
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Article
Open AccessSystemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—an autopsy study
Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have been recently approved for treatment of patients with metastatic mela...
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Polyomavirus
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Enterobiasis
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Amebiasis
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Herpes Virus
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Article
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
In mouse models of breast cancer, anti-CCL2 therapy—thought to be potentially useful in treating cancer—is shown to accelerate the growth of lung metastases on discontinuation due to a surge of recruitment of ...
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Article
MTSS1 is a metastasis driver in a subset of human melanomas
In cancers with a highly altered genome, distinct genetic alterations drive subsets rather than the majority of individual tumours. Here we use a sequential search across human tumour samples for transcript ou...
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Article
Progressive scoliosis in central core disease
Central core disease (CCD) is a rare congenital myopathy with autosomal dominant inheritance. Here, we report on two cases of progressive scoliosis in CCD, pointing out the value of a muscle biopsy to establis...
