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Open AccessAcceptability of COVID-19 booster vaccine in malaysia: a cross-sectional study
Despite the high efficacy and safety demonstrated in clinical trials, COVID-19 booster vaccination rates in Malaysia remain below 50% among the general public. This study explores the factors influencing publi...
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Article
Open AccessExploring the Causal Relationship Between Telomere Biology and Alzheimer’s Disease
Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell cycle due to the end replication problem. This process, termed telomere attrition, is associated with many age-related ...
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Article
Open AccessActive targeting via ligand-anchored pH-responsive strontium nanoparticles for efficient nucleic acid delivery into breast cancer cells
Gene therapy is a promising and novel therapeutic strategy for many mutated gene-associated diseases, including breast cancer. However, it poses significant biological drawbacks such as rapid clearance from th...
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Article
In vivo evaluation of biodistribution and toxicity of pH-responsive strontium nanoparticles for gene delivery
Low efficacy of parenteral administration of naked therapeutic genes is associated with the presence of biological barriers including circulatory monocytes that clear and eliminate foreign materials via reticu...
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Article
Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions
The endosomal-lysosomal system mediates the process of protein degradation through endocytic pathway. This system consists of early endosomes, late endosomes, recycling endosomes and lysosomes. Each component ...
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Article
Pharmacological Effects of Melatonin as Neuroprotectant in Rodent Model: A Review on the Current Biological Evidence
The progressive loss of structure and functions of neurons, including neuronal death, is one of the main factors leading to poor quality of life. Promotion of functional recovery of neuron after injury is a gr...
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Article
Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death
Extracellular senile plaques and intracellular neurofibrillary tangles are the neuropathological findings of the Alzheimer’s disease (AD). Based on the amyloid cascade hypothesis, the main component of senile ...
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Article
Tau Proteins and Tauopathies in Alzheimer’s Disease
Alzheimer’s disease (AD) is characterized by progressive memory loss and cognitive function deficits. There are two major pathological hallmarks that contribute to the pathogenesis of AD which are the presence...
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Article
Melatonin receptors: distribution in mammalian brain and their respective putative functions
Melatonin, through its different receptors, has pleiotropic functions in mammalian brain. Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated and non-receptor-mediated...
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Article
Open AccessEdible bird’s nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells
Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting the senile population with manifestation of motor disability and cognitive impairment. Reactive oxygen species (ROS) is i...
