158 Result(s)

Article

Ricin B chain fragments expressed inEscherichia coli are able to bind free galactose in contrast to the full length polypeptide

Deleted forms of ricin B chain (RTB) containing only one of the two galactose binding sites were produced inE. coli and targeted to the periplasm by fusion to theompA orompF signal sequences. The proteins were th...

Richard Wales, Hazel C. Gorham, Khalid Hussain, Lynne M. Roberts… in Glycoconjugate Journal (1994)

Article

A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene

Usher syndrome type 1 describes the association of profound, congenital sensorineural deafness, vestibular hypofunction and childhood onset retinitis pigmentosa¹. It is an autosomal recessive condition and is sub...

Maria Bitner-Glindzicz, Keith J. Lindley, Paul Rutland, Diana Blaydon… in Nature Genetics (2000)

Article

A child presenting with disordered consciousness, hallucinations, screaming episodes and abdominal pain

Khalid Hussain, Helen Mundy, Albert Aynsley-Green… in European Journal of Pediatrics (2002)

Article

Interactions of diazoxide with frusemide, spironolactone, and acetylsalicylic acid in a patient with hyperinsulinism of Infancy and Fallot tetralogy

Saji Alexander, Antoinette Anazodo, Khalid Hussain in European Journal of Pediatrics (2003)

Article

Ketotic hypoglycaemia in children with diazoxide responsive hyperinsulinism of infancy

Hyperinsulinism of infancy (HI) is a cause of persistent and recurrent hypoglycaemia in infancy and childhood, which if untreated can cause significant brain damage and mental retardation. The biochemical hall...

Khalid Hussain in European Journal of Pediatrics (2005)

Chapter

Hyperinsulinism of Infancy

Khalid Hussain in Physician’s Guide to the Treatment and Follow-Up of Metabolic Diseases (2006)

Article

From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation

Newborns with intrauterine growth retardation (IUGR) have multiple risk factors for develo** hypoglycaemia. Hyperinsulinism, both transient and prolonged, is one of the major risk factors responsible for th...

Inderpal Singh Kochar, Khalid Hussain in European Journal of Pediatrics (2007)

Reference Work Entry In depth

Ketotic Hypoglycaemia of Infancy

Khalid Hussain in Encyclopedia of Molecular Mechanisms of Disease (2009)

Article

Advances in the diagnosis and management of hyperinsulinemic hypoglycemia

Hyperinsulinemic hypoglycemia is a consequence of inappropriate and unregulated secretion of insulin by pancreatic β-cells. This Review provides an overview of the known genetic and nonhereditary causes and va...

Ritika R Kapoor, Chela James, Khalid Hussain in Nature Clinical Practice Endocrinology & M… (2009)

Chapter and Conference Paper

Energy-Efficient Intrusion Detection System for Wireless Sensor Network Based on MUSK Architecture

Wireless Sensor Network (WSN) is usually deployed in hostile and uncontrollable environment. The WSN is vulnerable to security threats due to its hostile nature. There are several static security techniques in...

Surraya Khanum, Muhammad Usman… in High Performance Computing and Applications (2010)

Article

Congenital Hyperinsulinism due to mutations in HNF4A and HADH

Mutations in the HADH and HNF4A genes are rare causes of diazoxide responsive congenital hyperinsulinism (CHI). This chapter details the phenotype known to be associated with mutations in these genes. Additionall...

Ritika R. Kapoor, Amanda Heslegrave… in Reviews in Endocrine and Metabolic Disorde… (2010)

Article

Pancreatic β-cell K_ATP channels: Hypoglycaemia and hyperglycaemia

The pancreatic β-cell ATP-sensitive K⁺ channel (K_ATP channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellu...

Kate Bennett, Chela James, Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

Article

Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus

Glucokinase is a key enzyme involved in regulating insulin secretion from the pancreatic ß-cell. The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in ...

Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

Article

Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism

Congenital hyperinsulinism is a leading cause of severe hypoglycaemia in the newborn period. There are two (diffuse and focal) histological subtypes of congenital hyperinsulinism. The diffuse form affects the ...

Dunia Ismail, Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

Article

Congenital hyperinsulinism and neonatal diabetes mellitus

This special edition of the Reviews in Metabolic and Endocrine Disorders provides a state of the state update on congenital hyperinsulinism and neonatal diabetes mellitus. Understanding the molecular mechanism...

Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

Article

Focal congenital hyperinsulinism in a patient with septo-optic dysplasia

This Case Study describes an infant diagnosed as having focal congenital hyperinsulinism associated with septo-optic dysplasia, highlighting the importance of maintaining a high degree of suspicion in all infa...

Raja Padidela, Ritika R. Kapoor, Yuva Moyo, Clare Gilbert… in Nature Reviews Endocrinology (2010)

Chapter and Conference Paper

Protocol Share Based Traffic Rate Analysis (PSBTRA) for UDP Bandwidth Attack

Internet is based on best effort and end to end design principles. Although they are the reasons for the Internet’s high efficiency and popularity, they also resulted in many inherent security problems such as...

Zohair Ihsan, Mohd. Yazid Idris… in Informatics Engineering and Information Sc… (2011)