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Open AccessUnlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma
Distinguishing benign from malignant pancreaticobiliary disease is challenging because of the absence of reliable biomarkers. Circulating extracellular vesicles (EVs) have emerged as functional mediators betwe...
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Article
Open AccessPsychological distress, wellbeing and resilience: modelling adolescent mental health profiles during the COVID-19 pandemic
There has been concern about adolescent mental health during the pandemic. The current study examined adolescent mental health during the initial phase of the COVID-19 pandemic in the UK. Using indicator of ps...
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Article
Correction: Integration of Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in Primary Care Settings
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Integration of Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in Primary Care Settings
The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) has been shown to improve food and economic security, advance health and educational outcomes, and reduce health costs. Despite...
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Article
Open AccessThe SEE-IT Trial: emergency medical services Streaming Enabled Evaluation In Trauma: a feasibility randomised controlled trial
Use of bystander video livestreaming from scene to Emergency Medical Services (EMS) is becoming increasingly common to aid decision making about the resources required. Possible benefits include earlier, more ...
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Open AccessSymptoms and levels of ICD-11 Prolonged Grief Disorder in a representative community sample of UK adults
Prolonged Grief Disorder (PGD) is a new disorder included in ICD-11 (WHO, 2018). There is a growing body of literature surrounding the prevalence and correlates of ICD-11 PGD symptoms as assessed using various...
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Open AccessThe Wellbeing in Place Perceptions Scale: Structure, Validity, Reliability and Correlates During COVID Times
The influence of place-based factors on the physical and mental health of residents is well established and acknowledged within the population health approach to addressing health and wellbeing inequalities. T...
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Open AccessModelling the complexity of pandemic-related lifestyle quality change and mental health: an analysis of a nationally representative UK general population sample
The COVID-19 pandemic has affected the way many individuals go about their daily lives. This study attempted to model the complexity of change in lifestyle quality as a result of the COVID-19 pandemic and its ...
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Open AccessDelay discounting and under-valuing of recent information predict poorer adherence to social distancing measures during the COVID-19 pandemic
The COVID-19 pandemic has brought about unprecedented global changes in individual and collective behaviour. To reduce the spread of the virus, public health bodies have promoted social distancing measures whi...
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Open AccessNew-onset IgG autoantibodies in hospitalized patients with COVID-19
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein arrays to measure IgG autoantibodies associated wit...
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Open AccessPsychological characteristics associated with COVID-19 vaccine hesitancy and resistance in Ireland and the United Kingdom
Identifying and understanding COVID-19 vaccine hesitancy within distinct populations may aid future public health messaging. Using nationally representative data from the general adult populations of Ireland (N =...
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Open AccessMetabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity
Several plasma metabolites have been associated with insulin resistance and type 2 diabetes mellitus.
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Open AccessMetabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease
We aimed to identify novel metabolite and lipid signatures connected with the metabolic syndrome in a Dutch middle-aged population.
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Open AccessHuman papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial)
Anogenital warts are the second most common sexually transmitted infection diagnosed in sexual health services in England. About 90% of genital warts are caused by human papillomavirus (HPV) types 6 or 11, and...
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Open AccessThe effects of thawing on the plasma metabolome: evaluating differences between thawed plasma and multi-organ samples
Post-collection handling, storage and transportation can affect the quality of blood samples. Pre-analytical biases can easily be introduced and can jeopardize accurate profiling of the plasma metabolome. Cons...
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Tissue sample stability: thawing effect on multi-organ samples
Correct handling of samples is essential in metabolomic studies. Improper handling and prolonged storage of samples has unwanted effects on the metabolite levels. The aim of this study was to identify the effe...
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Article
Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia
The pancreatic β-cell ATP-sensitive K+ channel (KATP channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellu...
