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  1. No Access

    Article

    Successful transitioning children and adolescents with type 1 diabetes from multiple daily injections to advanced hybrid closed-loop system in 10 days: a prospective intervention study on MiniMed 780G system

    Goran Petrovski, Fawziya Al Khalaf, Judith Campbell, Emma Day in Acta Diabetologica (2022)

  2. Article

    Open Access

    One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes

    To evaluate the effect of a 1-year hybrid closed-loop (HCL) system on glycemic control in children and adolescents with type 1 diabetes (T1D) previously treated with multiple daily injections (MDI).

    Goran Petrovski, Fawziya Al Khalaf, Judith Campbell, Fareeda Umer in Acta Diabetologica (2021)

  3. Article

    Open Access

    10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes

    The aim of this study was to evaluate the 10-day initiation protocol for MiniMed 670G hybrid closed-loop (HCL) system in individuals with type 1 diabetes on multiple daily injection (MDI) in achieving desirabl...

    Goran Petrovski, Fawziya Al Khalaf, Judith Campbell, Hannah Fisher in Acta Diabetologica (2020)

  4. Article

    Open Access

    Glucose control during Ramadan fasting in a teenager with type 1 diabetes on MiniMed 670G hybrid closed-loop system

    Goran Petrovski, Fawziya Al Khalaf, Judith Campbell, Khalid Hussain in Acta Diabetologica (2020)

  5. Article

    Open Access

    Optimizing a Hybrid Closed Loop System in Type 1 Diabetes: A Case Report

    We present the optimization of a hybrid closed-loop (HCL) insulin pump system in a type 1 diabetes (T1D) patient in the first 3 months of using the Minimed 670G. An 11-year-old female with 7 years of T1D histo...

    Goran Petrovski, Fawziya Al Khalaf, Khalid Hussain, Judith Campbell in Diabetes Therapy (2018)

  6. Article

    Open Access

    Continuous Subcutaneous Insulin Infusion Characteristics in Type 1 Diabetes Children and Adolescents in Qatar

    To describe continuous subcutaneous insulin infusion (CSII) characteristics in type 1 diabetes mellitus (T1DM) children and adolescents using a standardized protocol in routine clinical settings in Qatar.

    Goran Petrovski, Fawziya Al Khalaf, Khalid Hussain, Judith Campbell in Diabetes Therapy (2018)

  7. Article

    Open Access

    Diagnosis and treatment of hyperinsulinaemic hypoglycaemia and its implications for paediatric endocrinology

    Glucose homeostasis requires appropriate and synchronous coordination of metabolic events and hormonal activities to keep plasma glucose concentrations in a narrow range of 3.5–5.5 mmol/L. Insulin, the only gl...

    Huseyin Demirbilek, Sofia A. Rahman in International Journal of Pediatric Endocri… (2017)

  8. Article

    Open Access

    Fainting Fanconi syndrome clarified by proxy: a case report

    Rare diseases may elude diagnosis due to unfamiliarity of the treating physicians with the specific disorder. Yet, advances in genetics have tremendously enhanced our ability to establish specific and sometime...

    Stephen Benedict Walsh, Robert Unwin, Robert Kleta, William van’t Hoff in BMC Nephrology (2017)

  9. Article

    Open Access

    Sirolimus therapy following subtotal pancreatectomy in neonatal hyperinsulinemic hypoglycaemia: a case report

    Mary Abraham, Sarah Flanagan, Vinutha Shetty in International Journal of Pediatric Endocri… (2015)

  10. Article

    Open Access

    A novel homozygous SLC19A2 mutation in a Portuguese patient with diabetes mellitus and thiamine-responsive megaloblastic anaemia

    Thiamine-responsive megaloblastic anaemia (TRMA) is a rare syndrome where patients present with early onset diabetes mellitus, megaloblastic anaemia and sensorineural deafness. This report describes a new case...

    Sophia Tahir, Lieve GJ Leijssen, Maha Sherif in International Journal of Pediatric Endocri… (2015)

  11. Article

    Open Access

    Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy

    Mutations in ABCC8 and KCNJ11 are the most common cause of congenital hyperinsulinism (CHI). Recessive as well as dominant acting ABCC8/KCNJ11 mutations have been described. Diazoxide, which is the first line med...

    Ved Bhushan Arya, Qadeer Aziz, Azizun Nessa in International Journal of Pediatric Endocri… (2014)

  12. No Access

    Article

    Hyperinsulinaemic hypoglycaemia: genetic mechanisms, diagnosis and management

    Hyperinsulinaemic hypoglycaemia (HH) is due to the unregulated secretion of insulin from pancreatic β-cells. A rapid diagnosis and appropriate management of these patients is essential to prevent the potential...

    Senthil Senniappan, Balasubramaniam Shanti in Journal of Inherited Metabolic Disease (2012)

  13. No Access

    Reference Work Entry In depth

    Introduction to Endocrine Disorders

    Khalid Hussain in Textbook of Clinical Pediatrics (2012)

  14. No Access

    Reference Work Entry In depth

    Thyroid Disorders

    Senthil Senniappan, Khalid Hussain in Textbook of Clinical Pediatrics (2012)

  15. No Access

    Article

    Congenital Hyperinsulinism due to mutations in HNF4A and HADH

    Mutations in the HADH and HNF4A genes are rare causes of diazoxide responsive congenital hyperinsulinism (CHI). This chapter details the phenotype known to be associated with mutations in these genes. Additionall...

    Ritika R. Kapoor, Amanda Heslegrave in Reviews in Endocrine and Metabolic Disorde… (2010)

  16. No Access

    Article

    Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia

    The pancreatic β-cell ATP-sensitive K+ channel (KATP channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellu...

    Kate Bennett, Chela James, Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

  17. No Access

    Article

    Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus

    Glucokinase is a key enzyme involved in regulating insulin secretion from the pancreatic ß-cell. The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in ...

    Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

  18. No Access

    Article

    Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism

    Congenital hyperinsulinism is a leading cause of severe hypoglycaemia in the newborn period. There are two (diffuse and focal) histological subtypes of congenital hyperinsulinism. The diffuse form affects the ...

    Dunia Ismail, Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

  19. No Access

    Article

    Congenital hyperinsulinism and neonatal diabetes mellitus

    This special edition of the Reviews in Metabolic and Endocrine Disorders provides a state of the state update on congenital hyperinsulinism and neonatal diabetes mellitus. Understanding the molecular mechanism...

    Khalid Hussain in Reviews in Endocrine and Metabolic Disorders (2010)

  20. No Access

    Chapter

    Hyperinsulinism of Infancy

    Khalid Hussain in Physician’s Guide to the Treatment and Follow-Up of Metabolic Diseases (2006)