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Protocol
Miniature Microscopy of Hippocampal CA1 to Identify Engram Cells and Record Calcium Transients for Analyses of Ensemble Activities
In the brain, memories are thought to be stored by neurons termed engram cells that are activated during learning. Engram cells in the hippocampus can be targeted in c-Fos-tTA mice and have been identified as ...
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Article
Open AccessPcdhβ deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination
Clustered protocadherins (Pcdhs), a large group of adhesion molecules, are important for axonal projections and dendritic spread, but little is known about how they influence neuronal activity. The Pcdhβ clust...
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Article
Open AccessOrchestrated ensemble activities constitute a hippocampal memory engram
The brain stores and recalls memories through a set of neurons, termed engram cells. However, it is unclear how these cells are organized to constitute a corresponding memory trace. We established a unique ima...
