35 Result(s)

Article

Mainstreamed genetic testing of breast cancer patients: experience from a single surgeon’s practice in a large US Academic Center

This study evaluated the impact of mainstreamed genetic testing (MGT) on the timing and uptake of testing in an academic breast surgeon’s practice. Before September 2019 (pre-MGT phase), a breast surgery pract...

Teresa S. Chai, Kanhua Yin, Mackenzie Wooters, Kristen M. Shannon… in Familial Cancer (2023)

Article

Familial pancreatic cancer: who should be considered for genetic testing?

Determining how many female patients who underwent breast imaging meet the eligibility criteria for genetic testing for familial pancreatic cancer (FPC).

Kinyas Kartal, Zoe Guan, Rong Tang… in Irish Journal of Medical Science (1971 -) (2022)

Article

Penetrance of male breast cancer susceptibility genes: a systematic review

Several male breast cancer (MBC) susceptibility genes have been identified, but the MBC risk for individuals with a pathogenic variant in each of these genes (i.e., penetrance) remains unclear. We conducted a ...

Reem S. Chamseddine, Cathy Wang, Kanhua Yin… in Breast Cancer Research and Treatment (2022)

Article

Management and outcomes of men diagnosed with primary breast cancer

Fewer than 1% of all breast cancers occur in men. As a result, a distinct lack of data exists regarding the management and outcomes in this cohort.

Andrew E. Johnson, Suzanne B. Coopey… in Breast Cancer Research and Treatment (2021)

Article

Disease spectrum of gastric cancer susceptibility genes

Pathogenic variants in germline cancer susceptibility genes can increase the risk of a large number of diseases. Our study aims to assess the disease spectrum of gastric cancer susceptibility genes and to deve...

Sophia K. McKinley, Preeti Singh, Kanhua Yin, ** Wang, **gan Zhou… in Medical Oncology (2021)

Article

Incidental breast carcinoma: incidence, management, and outcomes in 4804 bilateral reduction mammoplasties

Bilateral reduction mammoplasty is one of the most common plastic surgery procedures performed in the U.S. This study examines the incidence, management, and prognosis of incidental breast cancer identified in...

Rong Tang, Francisco Acevedo, Conor Lanahan… in Breast Cancer Research and Treatment (2019)

Article

Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk?

Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men.

Suzanne B. Coopey, Kinyas Kartal, Clara Li… in Breast Cancer Research and Treatment (2019)

Article

Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions

Mammoplasty removes random samples of breast tissue from asymptomatic women providing a unique method for evaluating background prevalence of breast pathology in normal population. Our goal was to identify the...

Francisco Acevedo, V. Diego Armengol, Zhengyi Deng… in Breast Cancer Research and Treatment (2019)

Article

A Clinical Decision Support Tool to Predict Cancer Risk for Commonly Tested Cancer-Related Germline Mutations

The rapid drop in the cost of DNA sequencing led to the availability of multi-gene panels, which test 25 or more cancer susceptibility genes for a low cost. Clinicians and genetic counselors need a tool to int...

Danielle Braun, Jiabei Yang, Molly Griffin… in Journal of Genetic Counseling (2018)

Chapter

Breast Cancer Risk Prediction in Women with Atypical Breast Lesions

Women with atypical breast lesions have a markedly increased risk of develo** breast cancer. The risk of breast cancer in women with lobular carcinoma in situ is seven- to nine-fold that of the general popul...

Suzanne B. Coopey, Kevin S. Hughes in Atypical Breast Proliferative Lesions and … (2018)

Article

Reassessing risk models for atypical hyperplasia: age may not matter

The aim of this study was to investigate the influence of age at diagnosis of atypical hyperplasia (“atypia”, ductal [ADH], lobular [ALH], or severe ADH) on the risk of develo** subsequent invasive breast ca...

Emanuele Mazzola, Suzanne B. Coopey, Molly Griffin… in Breast Cancer Research and Treatment (2017)

Article

Breast cancer risk models: a comprehensive overview of existing models, validation, and clinical applications

Numerous models have been developed to quantify the combined effect of various risk factors to predict either risk of develo** breast cancer, risk of carrying a high-risk germline genetic mutation, specifica...

Jessica A. Cintolo-Gonzalez, Danielle Braun… in Breast Cancer Research and Treatment (2017)

Article

Using machine learning to parse breast pathology reports

Extracting information from electronic medical record is a time-consuming and expensive process when done manually. Rule-based and machine learning techniques are two approaches to solving this problem. In th...

Adam Yala, Regina Barzilay, Laura Salama… in Breast Cancer Research and Treatment (2017)

Chapter

Risk Assessment for Breast Cancer

Genetic testing for individuals with familial or hereditary risk for breast cancer is essential to improving prevention and survival. Identifying unaffected BRCA1/2 mutation carriers before they develop breast ca...

Anvy Nguyen, Jessica Cintolo-Gonzalez… in Managing BRCA Mutation Carriers (2017)

Article

Doing “nothing” for DCIS: a case report

Margo M. Moskos, Kevin S. Hughes in Breast Cancer Research and Treatment (2015)

Article

False-negative rate of combined mammography and ultrasound for women with palpable breast masses

Mammography and ultrasound are often used concurrently for patients with palpable breast masses. While mammography has a false-negative rate of approximately 15 %, the addition of breast ultrasound decreases t...

Carlos H. F. Chan, Suzanne B. Coopey… in Breast Cancer Research and Treatment (2015)