10 Result(s)
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Kevin M. Brindle
Cancer Research
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Article
Open AccessCorrection to: Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessMulti-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent
Ductal carcinoma in situ (DCIS) is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature of D...
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Article
Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose
One of the most likely substrates for metabolic imaging of response to treatment in cancer is glucose, but until now, using hyperpolarized 13C-labelled glucose has been problematic because of the short lifetim...
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Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus
Cell-surface glycans are known to alter as Barrett's esophagus progresses to adenocarcinoma, leading to specific changes in lectin binding patterns. Bird-Lieberman and her colleagues have exploited this knowle...
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Molecular Imaging of Cancer and the Implications for Pre-invasive Disease
The fluorescence microscope is a standard tool in any cell biology lab, enabling the visualisation of appropriately labelled probe molecules in the context of cell anatomy. These probe molecules can be used to...
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Article
Erratum: Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy
Nat. Med. 13, 1382–1387 (2007); published online 28 October 2007; corrected after print 12 November 2007. In the version of this article initially published, Equation 2 is incorrect. The correct equation is: A...
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Article
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy
Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-13C]pyruvate that the ...
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Article
Proton NMR analysis of plasma is a weak predictor of coronary artery disease
Multivariate analysis of 1H-NMR spectra of blood sera was reported previously to predict angiographically defined advanced coronary artery disease (CAD) with >90% accuracy and specificity. The analysis depended m...
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Article
Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent
The C2 domain of synaptotagmin I, which binds to anionic phospholipids in cell membranes, was shown to bind to the plasma membrane of apoptotic cells by both flow cytometry and confocal microscopy. Conjugation of...
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Chapter
Probing The Cell Interior With NMR Spectroscopy
NMR can give more chemical information than any other non-invasive spectroscopic technique for investigating cell biochemistry (Gadian, 1995; Gillies, 1994). The technique can give information about pathway flux
