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Management Strategies for Women at an Inherited High Risk of Breast Cancer
Since the identification of the autosomal dominant genes that carry a lifetime risk of acquiring breast and/or ovarian cancer in 60 to 80% of carriers, other high-risk mutated genes like TP53 PALPB2 and more m...
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Article
Open AccessBilateral Risk-Reducing Mastectomies with Implant-Based Reconstructions Followed Long Term: A Consecutive Series of 185 Patients
Bilateral risk-reducing mastectomy (BRRM) is the most effective method to prevent breast cancer in genetically predisposed women and is often performed concomitantly with breast reconstruction. The reconstruct...
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Article
Open AccessValidation of data quality in the Swedish National Register for Breast Cancer
The National Breast Cancer Register (NBCR) of Sweden was launched in 2008 and is used for quality assurance, benchmarking, and research. Its three reporting forms encompass Notification, Adjuvant therapy and F...
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Ethics and Breast Cancer
Enabling, empowering and educating a woman to make the right choice between breast-conserving surgery and mastectomy are aligned with the fundamental principle of bioethics, that is, respect for patient autono...
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Article
Stability of the 13-item sense of coherence (SOC) scale: a longitudinal prospective study in women treated for breast cancer
To test the stability of the SOC scale over time and to test the stability of the latent construct in 417 breast cancer patients at the time of diagnosis, after 1 year and in a subsample (n = 80) also 2 and 3 yea...
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Article
Preoperative MRI of the Breast (POMB) Influences Primary Treatment in Breast Cancer: A Prospective, Randomized, Multicenter Study
Breast magnetic resonance imaging (MRI) has shown high sensitivity in determining tumor extent, multifocality, and occult contralateral breast cancer. Low specificity, unnecessary mastectomies, and costs are a...
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Article
Open AccessNo difference in dose distribution in organs at risk in postmastectomy radiotherapy with or without breast implant reconstruction
The aim of this study was to quantify the variation in doses to organs at risk (ipsilateral lung and heart) and the clinical target volume (CTV) in the presence of breast implants. In this retrospective cohort...
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Article
Case-Based Learning in Surgery: Lessons Learned
The aim of the study was to obtain a deepened understanding of the implementation process of case-based learning (CBL) during a surgical semester at the Undergraduate Medical Program at Karolinska Institutet. ...
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Article
Polyacrylamide Gel Injections for Breast Augmentation: Management of Complications in 106 Patients, a Multicenter Study
Polyacrylamide gel (PAAG) was first manufactured in Ukraine in the late 1980s and introduced as a biomaterial for “breast augmentation without surgery.” Since it is prohibited in most countries, PAAG injection...
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Eleven-Year Follow-Up of a Randomized Study of Pectoral Fascia Preservation After Mastectomy for Early Breast Cancer
The present study reports results of a randomized trial in which breast cancer patients operated with preserved pectoral fascia compared to removal of the pectoral fascia showed a trend toward an increased ris...
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Article
Open AccessIs Breast Cancer the Same Disease in Asian and Western Countries?
A mini-symposium was held in Montreal, Canada, at the International Surgical Week for the Breast Surgical International in 2007 addressing the question whether breast cancer is the same disease in Asian and We...
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Breast Surgery International
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Oncoplastic Breast Surgery: A Global Perspective on Practice, Availability, and Training
Oncoplastic surgery is the seamless joining of the extirpative and reconstructive aspects of breast surgery that is performed by a single surgeon. A symposium was held at ISW 2007 in Montreal with a prearrange...
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Article
Non-palpable Breast Lesions: Sample or Excise?
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Open AccessGene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
Adjuvant breast cancer therapy significantly improves survival, but overtreatment and undertreatment are major problems. Breast cancer expression profiling has so far mainly been used to identify women with a ...
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Article
Evaluation of Retinoblastoma and Ki-67 Immunostaining as Diagnostic Markers of Benign and Malignant Parathyroid Disease
RID="" ID="" <E5>Correspondence to:</E5> F. Farnebo, M.D., Ph.D.
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Article
Outcome of treatment for ipsilateral breast tumor recurrence in early-stage breast cancer
Introduction: The aims of the study were to assess the outcome among patients with early breast cancer operated on with wide local excision who developed a subsequent ipsilateral breast tumor recurrence, and to i...
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Article
Differential loss of heterozygosity in familial, sporadic, and uremic hyperparathyroidism
Various genetic loci harboring oncogenes, tumor suppressor genes, and genes for calcium receptors have been implicated in the development of parathyroid tumors. We have carried out loss of heterozygosity (LOH...
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Parathyroid carcinoma
Parathyroid carcinoma is the rarest type of endocrine malignant tumor. Consequently, clinicians and pathologists not dealing with endocrine tumors will have a limited experience, which may affect the diagnosis...