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Chapter
The Hidden Layer of RNA Variants
The genome is pervasively transcribed and produces various messenger RNAs and noncoding RNAs. Defective transcripts are also produced, which are cleared by RNA surveillance and quality control systems. Nuclear...
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Article
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin
The accurate and early diagnosis and classification of cancer origin from either tissue or liquid biopsy is crucial for selecting the appropriate treatment and reducing cancer-related mortality. Here, we estab...
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Article
Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway
Mutations in GNAS drive pancreatic tumorigenesis and frequently occur in intraductal papillary mucinous neoplasm (IPMN); however, their value as a therapeutic target is yet to be determined. This study aimed at e...
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Article
Open AccessHuman U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis
Acute retinal necrosis (ARN) is a form of infectious uveitis caused by alpha herpesviruses, including herpes simplex virus type 1 (HSV-1). We previously found that the long non-coding RNA (lncRNA) U90926 is upreg...
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Article
Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance
Cell-free DNA (cfDNA) shed from tumors into the circulation offers a tool for cancer detection. Here, we evaluated the feasibility of cfDNA measurement and utility of digital PCR (dPCR)-based assays, which red...
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Article
Open AccessLong noncoding RNA U90926 is crucial for herpes simplex virus type 1 proliferation in murine retinal photoreceptor cells
Long non-coding RNAs (lncRNAs) play vital roles in the pathogenesis of infectious diseases, but the role of lncRNAs in herpes simplex virus 1 (HSV-1) infection remains unknown. Using RNA sequencing analysis, w...
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Article
UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells
The epigenetic factor UHRF1 regulates transcription by modulating DNA methylation and histone modification, and plays critical roles in proliferation, development, and tumorigenesis. Here, we show that Wnt/c-M...
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Article
Correction: Corrigendum: The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis
Nature Communications 5: Article number: 3150 (2014); Published: 23 January 2014; Updated: 22 May 2014. In the original version of this Article, the image in the left panel of Fig. 5e was inadvertently duplica...
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Article
The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis
Aberrant activation of Wnt signalling results in colorectal tumours. Lgr5 is specifically expressed in stem cells of the intestine and has an essential role in maintaining tissue homeostasis. Lgr5-positive ste...
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Article
Open AccessASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma
Mammalian genomes encode numerous antisense non-coding RNAs, which are assumed to be involved in the regulation of the sense gene expression. However, the mechanisms of their action and involvement in the deve...
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Article
Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway
Cell fusion has a critical role in various developmental processes, immune response, tissue homeostasis and regeneration, and possibly, in cancer. However, the signals that regulate cell fusion remain poorly u...
