-
Article
Open AccessADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
ADAR1 is involved in adenosine-to-inosine RNA editing. The cytoplasmic ADAR1p150 edits 3’UTR double-stranded RNAs and thereby suppresses induction of interferons. Loss of this ADAR1p150 function underlies the ...
-
Article
Metal coordination by L-amino acid oxidase derived from flounder Platichthys stellatus is structurally essential and regulates antibacterial activity
L-amino acid oxidases (LAAOs) have antibacterial activity and play important roles in innate immunity. We have previously identified a LAAO of ~52 kDa in size from the mucus layer of the flounder Platichthys stel...
-
Article
Open AccessRadiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles
Exosome-like vesicles (ELV) are involved in mediating radiation-induced bystander effect (RIBE). Here, we used ELV from control cell conditioned medium (CCCM) and from 4 Gy of X-ray irradiated cell conditioned...
-
Article
Radiation-induced bystander effect in large Japanese field mouse (Apodemus speciosus) embryonic cells
Although evidence suggests that ionizing radiation can induce the bystander effect (radiation-induced bystander effect: RIBE) in cultured cells or mouse models, it is unclear whether the effect occurs in cells...
-
Article
Dynamic landscape and regulation of RNA editing in mammals
Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of ...
-
Article
Rapid isolation of murine primary hepatocytes for chromosomal analysis
Primary hepatocyte culture is a crucial tool for investigations of liver function and for evaluating the toxic effects of drugs. In addition, chromosomal analysis of hepatocytes could also prove useful for und...
