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Article
Open AccessTUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation
Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop formation are known to impede S phase progression. Nonetheless, cancer cells continuously proliferate under such high-stressed cond...
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Article
Rare-earth ions as antibacterial agents for woven wool fabric
Woven fabrics were bestowed with antibacterial property by the simple adsorption of rare-earth metal ions, and the underlying mechanism was investigated using electron spin resonance (ESR) spectroscopy. The ad...
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Article
Open AccessModification of improved-genome editing via oviductal nucleic acids delivery (i-GONAD)-mediated knock-in in rats
Improved genome-editing via oviductal nucleic acids delivery (i-GONAD) is a new technology that facilitates in situ genome-editing of mammalian zygotes exiting the oviductal lumen. The i-GONAD technology has been...
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Article
Open AccessDevelopment of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells
Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hy...
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Article
Open AccessStructural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response
Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the ataxia-telangiectasia and Rad3-related protein (ATR)-mediated DNA ...
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Article
Open AccessProceedings of the Frontiers of Retrovirology Conference 2016
Oral presentations
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Article
Open AccessBRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay
BRAF (V-raf murine sarcoma viral oncogene homolog B1) is a serine-threonine protein kinase involved in cell survival, proliferation, and differentiation. The most common missense mutation of BRAF (mainly V600E) c...
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Article
Open AccessViral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1
Viral protein R (Vpr), a protein of human immunodeficiency virus type-1 (HIV-1) with various biological functions, was shown to be present in the blood of HIV-1-positive patients. However, it remained unclear ...
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Article
Identification of SNF2h, a Chromatin-Remodeling Factor, as a Novel Binding Protein of Vpr of Human Immunodeficiency Virus Type 1
Vpr, an accessory gene of human immunodeficiency virus type 1, encodes a virion-associated nuclear protein that plays an important role in the primary viral infection of resting macrophag...
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Article
The Nijmegen breakage syndrome gene and its role in genome stability
NBS1 is the key regulator of the RAD50/MRE11/NBS1 (R/M/N) protein complex, a sensor and mediator for cellular DNA damage response. NBS1 potentiates the enzymatic activity of MRE11 and directs the R/M/N complex...
