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Open AccessAuthor Correction: Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development
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Open AccessDerivation of human primordial germ cell-like cells in an embryonic-like culture
Primordial germ cells (PGCs) are the embryonic precursors of sperm and eggs. They transmit genetic and epigenetic information across generations. Given the prominent role of germline defects in diseases such a...
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Open AccessPlacental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development
Cardiogenic growth factors play important roles in heart development. Placental growth factor (PLGF) has previously been reported to have angiogenic effects; however, its potential role in cardiogenesis has no...
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Unlocking the promise of mRNA therapeutics
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical trials of mRNA therapeutics inc...
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Open AccessBlocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calci...
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Open AccessEpicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders
The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration has remained controversial due to a lack of suitable analytical tools. By combining genetic marker-independent line...
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Open AccessMigratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics o...
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VEGFA mRNA for regenerative treatment of heart failure
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Open AccessAn mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be c...
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Open AccessPhospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathop...
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Open AccessAmnion signals are essential for mesoderm formation in primates
Embryonic development is largely conserved among mammals. However, certain genes show divergent functions. By generating a transcriptional atlas containing >30,000 cells from post-implantation non-human primat...
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PHF7 directs cardiac reprogramming
Epigenetic barriers need to be surmounted in order to increase the efficiency of cardiac reprogramming. A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the ch...
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Regenerating the field of cardiovascular cell therapy
The retraction of >30 falsified studies by Anversa et al. has had a disheartening impact on the cardiac cell therapeutics field. The premise of heart muscle regeneration by the transdifferentiation of bone mar...
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Open AccessIntradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
Chemically modified mRNA is an efficient, biocompatible modality for therapeutic protein expression. We report a first-time-in-human study of this modality, aiming to evaluate safety and potential therapeutic ...
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Open AccessModified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing
Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically be...
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Open AccessCorrection: Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
Nature Communications 7: Article number: 10774 (2016); Published: 8 March 2016; Updated: 19 July 2016. The affiliation details for Boon-Seng Soh, Lei Bu and Ronald A. Li are incorrect in this Article. The corr...
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Open AccessEndothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
Coronary arteriogenesis is a central step in cardiogenesis, requiring coordinated generation and integration of endothelial cell and vascular smooth muscle cells. At present, it is unclear whether the cell fat...
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Erratum: Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells
Correction to: Cell Research (2014) 24:820–841. doi:10.1038/cr.2014.59; published online 9 May 2014 The protocol in the current study was developed using BIO as the GSK-3β inhibitor and works with other inhibi...
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Open AccessN-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment
The cardiac progenitor cells (CPCs) in the anterior heart field (AHF) are located in the pharyngeal mesoderm (PM), where they expand, migrate and eventually differentiate into major cell types found in the hea...
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Tolerance induction to human stem cell transplants with extension to their differentiated progeny
There is increasing interest in transplantation of human stem cells for therapeutic purposes. It would benefit future application if one could achieve their long-term acceptance and functional differentiation ...
