18 Result(s)
within
Kenneth L. van Golen
Oncology
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Article
The Third International Inflammatory Breast Cancer Conference
Inflammatory breast cancer (IBC) is the most aggressive and deadly form of breast cancer. Disease-specific research and conferences have been organized since 2008 with the intent to bring together experts in v...
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Article
Differential effects of vitamin D treatment on inflammatory and non-inflammatory breast cancer cell lines
Vitamin D is a known regulator of breast cancer cell proliferation, apoptosis, migration, invasion and differentiation in vitro. Recent studies have suggested a preventative role for vitamin D in breast cancer...
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Chapter
Molecules That Drive the Invasion and Metastasis of Inflammatory Breast Cancer
Invasion and metastasis represent two of the most critical and rate limiting steps of cancer progression. It is very well known that IBC is lympho-angioinvasive and appears to be metastatic upon inception. Th...
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Chapter
Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium
Cancer cells in the bone come from two sources: primary tumors or metastases from other tissues. Primary cancer of the bone is rare, with 2,370 new cases and 1,330 deaths expected in 2007. Primary cancer accou...
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Article
Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis
Background The Rho GTPases comprise one of the eight subfamilies of the Ras superfamily of monomeric GTP-binding proteins and are involved in cytoskeletal organization. Previously, using ...
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Article
Step** out of the flow: capillary extravasation in cancer metastasis
In order for cancer cells to successfully colonize a metastatic site, they must detach from the primary tumor using extracellular matrix-degrading proteases, intravasate and survive in the circulation, evade t...
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Article
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased (lymph)angiogenesis and th...
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Article
Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling
Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer with high metastatic potential. Most patients have lymph node involvement at the time of diagnosis and 1/3 of the patien...
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Article
The current understanding of the molecular determinants of inflammatory breast cancer metastasis
Inflammatory breast cancer is a highly aggressive and metastatic form of locally advanced breast cancer that carries a significantly worse prognosis than non-inflammatory breast cancers. Unfortunately, the mol...
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Article
Multiple Signaling Pathways are Activated During Insulin-like Growth Factor-I (IGF-I) Stimulated Breast Cancer Cell Migration
In order to display the full metastatic phenotype, the cancer cell must acquire the ability to migrate. In breast cancer, we have previously shown that insulin-like growth factor I (IGF-I) enhances cell motili...
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Article
RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast
Background. There is a need for reliable predictors of breast cancer aggressiveness that will further refine the staging classification and help guide the implementation of novel therapies. We have identified Rho...
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Article
Open AccessRegulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1
In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae...
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Article
Rho-Regulatory Proteins in Breast Cancer Cell Motility and Invasion
The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is becoming increasingly evident. This review will provide an overview of the role of the Rho-regulatory protein...
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Article
Inflammatory breast cancer: Relationship between growth factor signaling and motility in aggressive cancers
A variety of phenotypic characteristics are required for a cancer cell to successfully complete the metastatic cascade. Acquisition of a motile and invasive phenotype is one requirement for a cell to become me...
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Article
N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells
Neuroblastoma is a peripheral nervous system tumor that accounts for 8–10% of all solid childhood tumors. N-Myc is the most reliable prognostic indicator for neuroblastoma. Bcl-2 is detected in 40–60% of prima...
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Article
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the p...
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Article
WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a 5-year disease-free survival of less than 45%. Little is known about the genetic alterations that result in IBC. In our previous w...
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Article
Molecular biology of breast cancer metastasis Inflammatory breast cancer: clinical syndrome and molecular determinants
Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and pathologica...
