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Chapter
A Control Engineering Model for Resolving the TGF-β Paradox in Cancer
Although TGF-β is widely known to appear to function paradoxically as a tumor suppressor in normal cells, and as a tumor promoter in cancer cells, the underlying mechanisms by which a single cytokine plays such a...
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Article
Open AccessSoluble perlecan domain i enhances vascular endothelial growth factor-165 activity and receptor phosphorylation in human bone marrow endothelial cells
Immobilized recombinant perlecan domain I (PlnDI) binds and modulates the activity of heparin-binding growth factors, in vitro. However, activities for PlnDI, in solution, have not been reported. In this study, w...
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Chapter
Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium
Cancer cells in the bone come from two sources: primary tumors or metastases from other tissues. Primary cancer of the bone is rare, with 2,370 new cases and 1,330 deaths expected in 2007. Primary cancer accou...
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Article
Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis
Background The Rho GTPases comprise one of the eight subfamilies of the Ras superfamily of monomeric GTP-binding proteins and are involved in cytoskeletal organization. Previously, using ...
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Article
Step** out of the flow: capillary extravasation in cancer metastasis
In order for cancer cells to successfully colonize a metastatic site, they must detach from the primary tumor using extracellular matrix-degrading proteases, intravasate and survive in the circulation, evade t...
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Article
Open AccessChanges in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer
Prostate cancer (PCa) is no exception to the multi-step process of metastasis. As PCa progresses, changes occur within the microenvironments of both the malignant cells and their targeted site of metastasis, e...
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Chapter
Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion
Cancer cell metastasis is a complex process involving several well-characterized steps. To metastasize successfully, tumor cells must first detach from a primary mass, enter the blood circulation or lymphatics...
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Chapter
Prostate carcinoma skeletal metastases: Cross-talk between tumor and bone
The majority of men with progressive prostate cancer develop metastases with the skeleton being the most prevalent metastatic site. Unlike many other tumors that metastasize to bone and form osteolytic lesions...
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Article
The regulation of prostate cancer cell adhesion to human bone marrow endothelial cell monolayers by androgen dihydrotestosterone and cytokines
A previous study from our laboratory suggested that prostate cancer metastasis to bone may be mediated, in part, by preferential adhesion to human bone marrow endothelial (HBME) cells. Tumor cell adhesion to e...
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Article
Prostate Carcinoma Skeletal Metastases: Cross-talk between Tumor and Bone
The majority of men with progressive prostate cancer develop metastases with the skeleton being the most prevalent metastatic site. Unlike many other tumors that metastasize to bone and form osteolytic lesions...
