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Chapter
Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium
Cancer cells in the bone come from two sources: primary tumors or metastases from other tissues. Primary cancer of the bone is rare, with 2,370 new cases and 1,330 deaths expected in 2007. Primary cancer accou...
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Article
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased (lymph)angiogenesis and th...
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Article
Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling
Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer with high metastatic potential. Most patients have lymph node involvement at the time of diagnosis and 1/3 of the patien...
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Article
Multiple Signaling Pathways are Activated During Insulin-like Growth Factor-I (IGF-I) Stimulated Breast Cancer Cell Migration
In order to display the full metastatic phenotype, the cancer cell must acquire the ability to migrate. In breast cancer, we have previously shown that insulin-like growth factor I (IGF-I) enhances cell motili...
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Article
RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast
Background. There is a need for reliable predictors of breast cancer aggressiveness that will further refine the staging classification and help guide the implementation of novel therapies. We have identified Rho...
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Article
Rho-Regulatory Proteins in Breast Cancer Cell Motility and Invasion
The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is becoming increasingly evident. This review will provide an overview of the role of the Rho-regulatory protein...
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Article
N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells
Neuroblastoma is a peripheral nervous system tumor that accounts for 8–10% of all solid childhood tumors. N-Myc is the most reliable prognostic indicator for neuroblastoma. Bcl-2 is detected in 40–60% of prima...
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Article
WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a 5-year disease-free survival of less than 45%. Little is known about the genetic alterations that result in IBC. In our previous w...