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  1. No Access

    Chapter

    Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium

    Cancer cells in the bone come from two sources: primary tumors or metastases from other tissues. Primary cancer of the bone is rare, with 2,370 new cases and 1,330 deaths expected in 2007. Primary cancer accou...

    Carlton R. Cooper, Robert A. Satcher, Lisa A. Gurski… in Bone and Cancer (2009)

  2. No Access

    Article

    Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer

    Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased (lymph)angiogenesis and th...

    Gert G. Van den Eynden, Steven J. Van Laere… in Breast Cancer Research and Treatment (2006)

  3. No Access

    Article

    Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling

    Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer with high metastatic potential. Most patients have lymph node involvement at the time of diagnosis and 1/3 of the patien...

    Steven J. Van Laere, Gert G. Van den Eynden… in Breast Cancer Research and Treatment (2006)

  4. No Access

    Article

    Multiple Signaling Pathways are Activated During Insulin-like Growth Factor-I (IGF-I) Stimulated Breast Cancer Cell Migration

    In order to display the full metastatic phenotype, the cancer cell must acquire the ability to migrate. In breast cancer, we have previously shown that insulin-like growth factor I (IGF-I) enhances cell motili...

    **hong Zhang, Min Lin, Kenneth L. van Golen… in Breast Cancer Research and Treatment (2005)

  5. No Access

    Article

    RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast

    Background. There is a need for reliable predictors of breast cancer aggressiveness that will further refine the staging classification and help guide the implementation of novel therapies. We have identified Rho...

    Celina G. Kleer, Kent A. Griffith, Michael S. Sabel… in Breast Cancer Research and Treatment (2005)

  6. No Access

    Article

    Rho-Regulatory Proteins in Breast Cancer Cell Motility and Invasion

    The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is becoming increasingly evident. This review will provide an overview of the role of the Rho-regulatory protein...

    Min Lin, Kenneth L. van Golen in Breast Cancer Research and Treatment (2004)

  7. No Access

    Article

    N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells

    Neuroblastoma is a peripheral nervous system tumor that accounts for 8–10% of all solid childhood tumors. N-Myc is the most reliable prognostic indicator for neuroblastoma. Bcl-2 is detected in 40–60% of prima...

    Daniel Noujaim, Cynthia M van Golen, Kenneth L van Golen, Alyssa Grauman… in Oncogene (2002)

  8. No Access

    Article

    WISP3 is a novel tumor suppressor gene of inflammatory breast cancer

    Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a 5-year disease-free survival of less than 45%. Little is known about the genetic alterations that result in IBC. In our previous w...

    Celina G Kleer, Yanhong Zhang, Quintin Pan, Kenneth L van Golen, Zhi-Fen Wu… in Oncogene (2002)