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Article
Adaptations of avian flu virus are a cause for concern
Members of the US National Science Advisory Board for Biosecurity explain its recommendations on the communication of experimental work on H5N1 influenza.
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Article
Site-specific integration by adeno-associated virus: a basis for a potential gene therapy vector
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Book
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Chapter
Cloning of the Adeno-Associated Virus Genome
The adeno-associated viruses (AAV) are defective parvoviruses that are dependent on coinfection with either adenovirus or herpesvirus for replication to occur (1–4). AAV has a linear single-strand DNA genome a...
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Chapter
The Genetics of Adeno-Associated Virus
Adeno-associated virus (AAV) is a defective parvovirus which is absolutely dependent on coinfection with a helper virus for a productive lytic cycle (for a review, see ref. 1). Either adenoviruses or herpes vi...
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Chapter
Mechanism of Adeno-Associated Virus Latent Infection
Adeno-associated virus (AAV) is a defective parvovirus with a linear, single-stranded DNA genome. In the absence of a helper virus coinfection AAV DNA is uncoated in the nucleus and can integrate into the cell...
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Chapter
Biology of Adeno-Associated Virus
The helper-dependent adeno-associated viruses (AAV) are widely distributed throughout nature and have been isolated as infecting agents in almost every animal species where a serious attempt has been made to f...
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Chapter
Adeno-Associated Virus
Adeno-associated virus (AAV) was discovered as a contaminant of purified adenovirus preparations. Although the small icosahedral particles (diameter 18–28 nm) were initially considered to be either precursors ...
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Chapter
Adeno-Associated Virus DNA Structure and Replication
The primary structure of adeno-associated virus (AAV) DNA has been pivotal in understanding its replication. The nucleotide sequence arrangement in virion DNA and the structure of replicative forms have sugges...
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Chapter
Molecular Biology of the Adeno-Associated Viruses
The adeno-associated viruses (AAV) are small, defective, DNA viruses which require co-infection with an adenovirus for productive infection (Atchison et al., 1965; Hoggan et al., 1966; Smith et al., 1966; Parks e...
