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Article
Open AccessCancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs ...
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Article
Treat wasting illness on multiple fronts
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Article
Understanding the mechanisms and treatment options in cancer cachexia
Cancer cachexia is a metabolic syndrome that is defined by loss of muscle mass. This syndrome can cause a great deal of distress to patients with cancer and their families. This Review article outlines the sym...
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Article
Open AccessIs there a genetic cause of appetite loss?—an explorative study in 1,853 cancer patients
Appetite loss has a major impact on cancer patients. It is exceedingly prevalent, is a prognostic indicator and is associated with inferior quality of life. Cachexia is a multi-factorial syndrome defined by a ...
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Article
Open AccessMyopenia—a new universal term for muscle wasting
A universal term describing the presence of clinically relevant muscle wasting that warrants medical intervention is required. The term sarcopenia might be used in this context. However, common use now means t...
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Article
Characterization of a cancer cachectic factor
CANCER cachexia is a syndrome of progressive wasting which has been suggested to be mediated by tumour-necrosis factor-α (ref. 1), interleukins 1 and 6 (ref. 2), interferon-γ (ref. 3) and leukaemia-inhibitory ...
