7 Result(s)
within
Kenichi Nagase
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessChromatography columns packed with thermoresponsive-cationic-polymer-modified beads for therapeutic drug monitoring
Therapeutic drug monitoring, which is used to determine appropriate drug doses, is critical in pharmacological therapy. In this study, we developed thermoresponsive chromatography columns with various cationic...
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Article
Open AccessTemperature-responsive mixed-mode column for the modulation of multiple interactions
In this study, mixed-mode chromatography columns have been investigated using multiple analyte interactions. A mixed-mode chromatography column was developed using poly(N-isopropylacrylamide) (PNIPAAm) brush-modi...
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Article
Open AccessTwo-dimensional temperature-responsive chromatography using a poly(N-isopropylacrylamide) brush-modified stationary phase for effective therapeutic drug monitoring
Therapeutic drug monitoring (TDM) is an effective pharmacological approach for controlling drug concentration in a patient’s serum. Herein, a new two-dimensional chromatography system was developed using two p...
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Article
Open AccessTemperature responsive chromatography for therapeutic drug monitoring with an aqueous mobile phase
Therapeutic drug monitoring is a key technology for effective pharmacological treatment. In the present study, a temperature-responsive chromatography column was developed for safe and simple therapeutic drug ...
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Article
Open AccessEffect of pore diameter on the elution behavior of analytes from thermoresponsive polymer grafted beads packed columns
Temperature-responsive chromatography using thermoresponsive polymers is innovative and can control analyte retention via column temperature. Analyte elution behavior in this type of chromatography depends on ...
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Article
Open AccessAntibody drug separation using thermoresponsive anionic polymer brush modified beads with optimised electrostatic and hydrophobic interactions
Antibody drugs play an important role in biopharmaceuticals, because of the specificity for target biomolecules and reduction of side effects. Thus, separation and analysis techniques for these antibody drugs ...
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Article
Open AccessGreen analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography
High-performance liquid chromatography (HPLC) is the most common analytical method practiced in various fields and used for analysis of almost all drug compounds in the pharmaceutical industries. During drug d...
