5 Result(s)
within
Ken-ichiro Kamei
English
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Article
Open AccessModeling dry eye with an air–liquid interface in corneal epithelium-on-a-chip
Dry eye syndrome (DES) is a complex ocular condition characterized by an unstable tear film and inadequate tear production, leading to tissue damage. Despite its common occurrence, there is currently no compre...
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Article
Open AccessIntegrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) afflicts a significant percentage of the population; however, no effective treatments have yet been established because of the unsuitability of in vitro assays and ani...
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Article
Open AccessTumor-on-a-chip model for advancement of anti-cancer nano drug delivery system
Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors in the last few decades, clinical translation rates are low owing to the lack of efficient models for evaluatin...
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Article
Open AccessIn vitro culture at 39 °C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions
Hepatocyte-like cells derived from human pluripotent stem cells (hPSC-HLCs) offer an alternative to primary hepatocytes commonly used for drug screenings and toxicological tests. However, these cells do not ha...
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Article
Open AccessLocalized cell stimulation by nitric oxide using a photoactive porous coordination polymer platform
Functional cellular substrates for localized cell stimulation by small molecules provide an opportunity to control and monitor cell signalling networks chemically in time and space. However, despite improvemen...
