9 Result(s)

Article

The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism

Previous research has suggested that thyroid hormone receptor alpha 1 (THRα1), a hormone responsive splice variant, may play a role in breast cancer progression. Whether THRα1 can be exploited for anti-cancer ...

Mitchell J. Elliott, Katarzyna J. Jerzak, Jessica G. Cockburn… in Scientific Reports (2018)

Article

Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro

In the original version of this Article, financial support was not fully acknowledged. This error has now been corrected in both the PDF and HTML versions of the Article.

Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester… in Nature Communications (2018)

Article

Gene isoforms as expression-based biomarkers predictive of drug response in vitro

Next-generation sequencing technologies have recently been used in pharmacogenomic studies to characterize large panels of cancer cell lines at the genomic and transcriptomic levels. Among these technologies, ...

Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester… in Nature Communications (2017)

Article

Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer

While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate cancer (CRPC). Emerging evidence suggests that ab...

Pier-Luc Clermont, Francesco Crea, Yan Ting Chiang, Dong Lin… in Clinical Epigenetics (2016)

Article

Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology

Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic tissues are largely uncharted. We analyzed 6,260 h...

Victor D. Martinez, Emily A. Vucic, Kelsie L. Thu, Roland Hubaux… in Scientific Reports (2015)

Article

Polycomb-mediated silencing in neuroendocrine prostate cancer

Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PCa) for which the median survival remains less than a year. Current treatments are only palliative in nature, and the l...

Pier-Luc Clermont, Dong Lin, Francesco Crea, Rebecca Wu, Hui Xue… in Clinical Epigenetics (2015)

Article

Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology

Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhib...

Emily A Vucic, Kelsie L Thu, Larissa A Pikor, Katey SS Enfield, John Yee… in BMC Cancer (2014)

Article

Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer

Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC...

Victor D Martinez, Emily A Vucic, Larissa A Pikor, Kelsie L Thu… in Molecular Cancer (2013)

Article

miRNA expression in human lung cancer and fetal lung: a comparative study

Daiana D Becker-Santos, Kelsie L Thu, Patricia P Reis, Wendy P Robinson… in BMC Proceedings (2013)