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Open AccessChallenges in selecting admixture models and marker sets to infer genetic ancestry in a Brazilian admixed population
The inference of genetic ancestry plays an increasingly prominent role in clinical, population, and forensic genetics studies. Several genoty** strategies and analytical methodologies have been developed ove...
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Article
Open AccessCorrection: The oldest unvaccinated Covid-19 survivors in South America
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Open AccessThe oldest unvaccinated Covid-19 survivors in South America
Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied thr...
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Open AccessAuthor Correction: Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil
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Open AccessWhole-genome sequencing of 1,171 elderly admixed individuals from Brazil
As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we presen...
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Article
Open AccessOrigin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations
The mutation age and local ancestry of chromosomal segments harbouring mutations associated with autosomal recessive (AR) disorders in Brazilian admixed populations remain unknown; additionally, inbreeding lev...
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Open AccessSelection scan reveals three new loci related to high altitude adaptation in Native Andeans
The Andean Altiplano has been occupied continuously since the late Pleistocene, ~12,000 years ago, which places the Andean natives as one of the most ancient populations living at high altitudes. In the presen...
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Open AccessA genomic perspective on HLA evolution
Several decades of research have convincingly shown that classical human leukocyte antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many questions remain regarding the type of ...
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Article
Open AccessIncreasing The Genetic Admixture of Available Lines of Human Pluripotent Stem Cells
Human pluripotent stem cells (hPSCs) may significantly improve drug development pipeline, serving as an in vitro system for the identification of novel leads, and for testing drug toxicity. Furthermore, these cel...
