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Article
Open AccessCapsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress
Early life stress (ELS) is associated with the later development of schizophrenia. In the rodent model, the maternal separation (MS) stress may induce neuronal apoptosis and schizophrenia-like behavior. Althou...
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Article
Open AccessNicotinamide ameliorates mitochondria-related neuronal apoptosis and cognitive impairment via the NAD+/SIRT3 pathway
Emerging evidence suggests that mitochondria play a central role in mental health disorders including schizophrenia. Here we investigated whether nicotinamide (NAM) normalized cognitive impairment via a mechan...
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Article
Open AccessNicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation
Early life stress (ELS) is associated with the development of schizophrenia later in life. The hippocampus develops significantly during childhood and is extremely reactive to stress. In rodent models, ELS can...
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Article
Open AccessAge-related changes in neuroinflammation and prepulse inhibition in offspring of rats treated with Poly I:C in early gestation
Maternal immune activation (MIA) during gestation can increase the later risk of schizophrenia in adult offspring. Neuroinflammation is believed to underlie this process. Postmortem brain studies have found ch...
