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  1. Article

    Open Access

    Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells

    NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which ...

    Keizo Kohno, Satomi Koya-Miyata, Akira Harashima… in Journal of Inflammation (2021)

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  2. Article

    Open Access

    Anti-inflammatory effects of adenosine N1-oxide

    Adenosine is a potent endogenous anti-inflammatory and immunoregulatory molecule. Despite its promise, adenosine’s extremely short half-life in blood limits its clinical application. Here, we examined adenosin...

    Keizo Kohno, Emiko Ohashi, Osamu Sano, Hajime Kusano… in Journal of Inflammation (2015)

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  3. No Access

    Article

    Antimicrobial activity of Polygonum tinctorium Lour: extract against oral pathogenic bacteria

    Extract of the leaves of the indigo plant (Polygonum tinctorium Lour.) was examined for antimicrobial activity against oral pathogenic bacteria. The indigo plant extract at concentrations of 1.74–3.48 mg/ml inhib...

    Kanso Iwaki, Satomi Koya-Miyata, Keizo Kohno, Shimpei Ushio… in Journal of Natural Medicines (2006)

  4. No Access

    Article

    Simultaneous exposure to interleukin-18 and interleukin-10 in vitro synergistically augments murine spleen natural killer cell activity

    Interleukin-18 (IL-18) enhances interferon γ (IFNγ) production and natural killer (NK) cell activity, and elicits protective antitumor effects in vivo. IL-18 and IL-12 synergistically augment IFNγ production ...

    Mark J. Micallef, Tadao Tanimoto, Kakuji Torigoe… in Cancer Immunology, Immunotherapy (1999)

  5. No Access

    Article

    In vivo antitumor effects of murine interferon- γ -inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites

    Interferon-γ-inducing factor/interleukin-18 is a novel cytokine that reportedly augments natural killer (NK) activity in human and mouse peripheral blood mononuclear cell cultures in vitro and has recently be...

    M. J. Micallef, Kenshi Yoshida, Sachiko Kawai… in Cancer Immunology, Immunotherapy (1997)